(Q28553478)

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Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems

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scholarly article

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Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems (English)

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infectious disease

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Schistosoma mansoni

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Alberto Bresciani

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Giovina Ruberti

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Edith Monteagudo

6

object named as

Edith Monteagudo

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Alessandra Guidi

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Cristiana Lalli

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Emerald Perlas

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Giulia Bolasco

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Martina Nibbio

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

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publication date

August 2016

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PLoS Neglected Tropical Diseases

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

e0004928

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

copyright license

Creative Commons Attribution 4.0 International

12 August 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

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1 reference

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19 March 2017

Comparative study of transcriptome profiles of mechanical- and skin-transformed Schistosoma mansoni schistosomula

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

19 March 2017

Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viability

1 reference

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19 March 2017

Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni

1 reference

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19 March 2017

Pharmacogenetics, drug-metabolizing enzymes, and clinical practice

1 reference

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19 March 2017

Drug binding to human alpha-1-acid glycoprotein in health and disease

1 reference

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19 March 2017

Use of 'dilute-and-shoot' liquid chromatography-high resolution mass spectrometry in preclinical research: application to a DMPK study of perhexiline in mouse plasma.

1 reference

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29 September 2017

Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni

1 reference

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29 September 2017

The metabolic control of schistosome egg production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Serum albumin and α-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib

1 reference

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29 September 2017

Gonad RNA-specific qRT-PCR analyses identify genes with potential functions in schistosome reproduction such as SmFz1 and SmFGFRs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Schistosomiasis control: praziquantel forever?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Disposition of mefloquine and enpiroline is highly influenced by a chronic Schistosoma mansoni infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Cell death and reproductive regression in female Schistosoma mansoni

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Something worth dyeing for: molecular tools for the dissection of lipid metabolism in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Schistosoma mansoni: signal transduction processes during the development of the reproductive organs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Myocardial fatty acid metabolism in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Metabolic therapeutics in angina pectoris: history revisited with perhexiline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Reinfection with Schistosoma haematobium and mansoni despite repeated praziquantel office treatment in Niger, Mali

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Schistosome male-female interaction: induction of germ-cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

29 September 2017

Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent

1 reference

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29 September 2017

Properties of four acute phase proteins: C-reactive protein, serum amyloid A protein, alpha 1-acid glycoprotein, and fibrinogen

1 reference

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Effects of phenformin and alpha-bromopalmitate on fatty acid and glucose oxidation in muscle

1 reference

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29 September 2017

Schistosoma mansoni: a comparative study of artificially transformed schistosomula and schistomula recoverd after cercarial penetration of isolated skin

1 reference

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Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients

1 reference

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3 June 2018

Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady-state dose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

3 June 2018

Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat

1 reference

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3 June 2018

Reproductive development of female Schistosoma mansoni (Digenea: Schistosomatidae) following bisexual pairing of worms and worm segments.

1 reference

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A comparative study of the reproductive system of mature, immature and "unisexual" female Schistosoma mansoni.

1 reference

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1 reference

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3 June 2018

Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment

1 reference

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Reinfection with Schistosoma haematobium following school-based chemotherapy with praziquantel in four highly endemic villages in Côte d'Ivoire

1 reference

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21 January 2018

Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific.

1 reference

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21 January 2018

Response of Schistosoma mansoni isolates having different drug sensitivity to praziquantel over several life cycle passages with and without therapeutic pressure

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0004928

21 January 2018

Determination of ED50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0004928

21 January 2018

Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy.

1 reference

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21 January 2018

Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0004928

21 January 2018

Drug-metabolizing enzymes and praziquantel bioavailability in mice harboring Schistosoma mansoni isolates of different drug susceptibilities.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0004928

21 January 2018

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1 reference

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21 January 2018

Presidential address. Sex and schistosomes: an interesting biological interplay with control implications.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0004928

21 January 2018

A perfusion technic for recovery of Schistosoma mansoni from experimentally infected guinea pigs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4982595

27 November 2018

Intergeneric reproductive stimulation and parthenogenesis in Schistosoma mansoni

1 reference

https://pubmed.ncbi.nlm.nih.gov/27518281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Laboratory induced resistance to praziquantel in experimental schistosomiasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27518281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical Evaluation of Perhexiline Maleate in Patients with Angina Pectoris

1 reference

https://pubmed.ncbi.nlm.nih.gov/27518281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical and pharmacokinetic study of praziquantel in Egyptian schistosomiasis patients with and without liver cell failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/27518281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Studies on resistance of Schistosoma to praziquantel XIII resistance of Schistosoma japonicum to praziquantel is experimentally induced in laboratory]

1 reference

https://pubmed.ncbi.nlm.nih.gov/27518281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails

1 reference

https://pubmed.ncbi.nlm.nih.gov/27518281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/27518281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PNTD.0004928

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518281%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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