(Q28556399)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

14 February 2019

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c

GOA

curator

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

3 references

nuclear receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

enzyme activator activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

protein-containing complex binding

1 reference

14 February 2019

Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

protein dimerization activity

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

14 February 2019

Calorie restriction modulates renal expression of sterol regulatory element binding proteins, lipid accumulation, and age-related renal disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

2 references

endoplasmic reticulum

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

endoplasmic reticulum membrane

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P56720&geneProductId=UniProtKB:P56720

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

ER to Golgi transport vesicle membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

2 references

integral component of membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

protein-containing complex

1 reference

14 February 2019

Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

intracellular membrane-bounded organelle

IDA

1 reference

14 February 2019

Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

endoplasmic reticulum membrane

IDA

2 references

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

regulation of heart rate by chemical signal

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

1 reference

14 February 2019

Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

steroid metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

insulin receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

lipid biosynthetic process

3 references

14 February 2019

Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

response to organic cyclic compound

1 reference

14 February 2019

Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

regulation of fatty acid metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

1 reference

14 February 2019

Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

intracellular receptor signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

positive regulation of histone deacetylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

regulation of protein stability

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

1 reference

14 February 2019

Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

response to retinoic acid

1 reference

14 February 2019

An adipogenic basic helix-loop-helix-leucine zipper type transcription factor (ADD1) mRNA is expressed and regulated by retinoic acid in osteoblastic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

Progesterone stimulates adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c gene expression. potential mechanism for the lipogenic effect of progesterone in adipose tissue

response to progesterone

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

1 reference

14 February 2019

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

1 reference

14 February 2019

ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

1 reference

14 February 2019

Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

mRNA transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

positive regulation of catalytic activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

response to peptide hormone

1 reference

14 February 2019

Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

fat cell differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

positive regulation of cholesterol biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

negative regulation of insulin secretion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

regulation of insulin secretion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

1 reference

14 February 2019

ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways

response to fatty acid

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

cellular response to fatty acid

1 reference

14 February 2019

Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

regulation of autophagy of mitochondrion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720

regulation of protein targeting to mitochondrion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56720