(Q28573343)

31 January 2017

title

Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria (English)

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31 January 2017

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reactive oxygen species

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Seiji Nakamura

1

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31 January 2017

Toshinari Takamura

2

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31 January 2017

Naoto Matsuzawa-Nagata

3

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31 January 2017

Hiroaki Takayama

4

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31 January 2017

Hirofumi Misu

5

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31 January 2017

Hiroyo Noda

6

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31 January 2017

Satoko Nabemoto

7

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31 January 2017

Seiichiro Kurita

8

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31 January 2017

Tsuguhito Ota

9

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31 January 2017

Hitoshi Ando

10

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31 January 2017

Ken-Ichi Miyamoto

11

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31 January 2017

Shuichi Kaneko

12

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31 January 2017

language of work or name

English

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publication date

29 May 2009

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Journal of Biological Chemistry

31 January 2017

published in

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31 January 2017

volume

284

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31 January 2017

issue

22

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31 January 2017

page(s)

14809–14818

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Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism

31 January 2017

cites work

1 reference

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

19 March 2017

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TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

19 March 2017

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Biochemistry and molecular cell biology of diabetic complications

19 March 2017

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Insulin signalling and the regulation of glucose and lipid metabolism

19 March 2017

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

19 March 2017

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Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

19 March 2017

1 reference

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Signal transduction by the JNK group of MAP kinases

19 March 2017

1 reference

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

19 March 2017

1 reference

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Metabolic aspects of peroxisomal beta-oxidation

19 March 2017

1 reference

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Increased oxidative stress in obesity and its impact on metabolic syndrome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

23 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

Reactive oxygen species have a causal role in multiple forms of insulin resistance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

A central role for JNK in obesity and insulin resistance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

NADPH oxidase in the liver: defensive, offensive, or fibrogenic?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

Oxidative stress and the JNK pathway as a potential therapeutic target for diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

Transcriptional and translational control in the Mammalian unfolded protein response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2685662

Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet.

3 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M901488200

SREBPs suppress IRS-2-mediated insulin signalling in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M901488200

Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M901488200

Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M901488200

Modulation of the JNK pathway in liver affects insulin resistance status

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M901488200

Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M901488200

Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M901488200

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M901488200

Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis

21 January 2018

1 reference

12 December 2020

Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease

1 reference

12 December 2020

It's what you do with the fat that matters!

1 reference

12 December 2020

Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M901488200

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