(Q28556420)

SH3-like domain superfamily

1 reference

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

1 reference

SH2 domain superfamily

1 reference

C2 domain superfamily

1 reference

PH-like domain superfamily

1 reference

EF-hand domain pair

1 reference

EF-hand domain, protein family

1 reference

pleckstrin homology domain, protein family

1 reference

SH2 domain, protein family

1 reference

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain, protein family

1 reference

C2 domain, protein family

1 reference

PLC-gamma, C-terminal SH2 domain, protein family

1 reference

Phosphatidylinositol-specific phospholipase C, X domain, protein family

1 reference

PLC-gamma, N-terminal SH2 domain, protein family

1 reference

Phospholipase C, phosphatidylinositol-specific, Y domain, protein family

1 reference

SH3 domain, protein family

1 reference

EF-Hand 1, calcium-binding site, protein family

1 reference

phosphatidylinositol phospholipase C activity

1 reference

25 May 2022

1 reference

25 May 2022

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor

IBA

insulin receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

11 references

14 February 2019

TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIα in rat hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

Direct protein-protein interaction between PLCgamma1 and the bradykinin B2 receptor--importance of growth conditions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

AP180 binds to the C-terminal SH2 domain of phospholipase C-gamma1 and inhibits its enzymatic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

Identification of p115 as a PLCgamma1-binding protein and the role of Src homology domains of PLCgamma1 in the vesicular transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

phosphoric diester hydrolase activity

IBA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor

IEA

phosphoprotein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

2 references

1 reference

14 February 2019

Overexpression of kidney phosphatidylinositol 4-kinasebeta and phospholipase C(gamma1) proteins in two rodent models of polycystic kidney disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10686&geneProductId=UniProtKB:P10686

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

2 references

clathrin-coated vesicle

1 reference

14 February 2019

AP180 binds to the C-terminal SH2 domain of phospholipase C-gamma1 and inhibits its enzymatic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

1 reference

14 February 2019

Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

2 references

3 references

14 February 2019

Overexpression of kidney phosphatidylinositol 4-kinasebeta and phospholipase C(gamma1) proteins in two rodent models of polycystic kidney disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

1 reference

14 February 2019

Identification of p115 as a PLCgamma1-binding protein and the role of Src homology domains of PLCgamma1 in the vesicular transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

phospholipid catabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

1 reference

14 February 2019

Small GTPase Ras and Rho expression in rat osteoblasts during spaceflight

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

response to organonitrogen compound

IEP

1 reference

14 February 2019

Polyamines are required for phospholipase C-gamma1 expression promoting intestinal epithelial restitution after wounding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

IEP

lipid catabolic process

1 reference

14 February 2019

inositol trisphosphate biosynthetic process

IEA

1 reference

1 January 2018

Polyamines are required for phospholipase C-gamma1 expression promoting intestinal epithelial restitution after wounding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P10686&geneProductId=UniProtKB:P10686

intracellular signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

response to hydrogen peroxide

IEA

1 reference

14 February 2019

Activation of H2O2-induced VSOR Cl- currents in HTC cells require phospholipase Cgamma1 phosphorylation and Ca2+ mobilisation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

1 reference

14 February 2019

Regulation of neuronal PLCgamma by chronic morphine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

cellular response to epidermal growth factor stimulus

IEP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

regulation of store-operated calcium channel activity

ISS

1 reference

14 February 2019

Phospholipase C-gamma1 is required for the activation of store-operated Ca2+ channels in liver cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

Phospholipase C-gamma is required for agonist-induced Ca2+ entry

calcium ion transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

phosphatidylinositol-mediated signaling

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

release of sequestered calcium ion into cytosol

IBA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686

1 reference

EF-hand domain

1 reference

C2 domain

1 reference

EF-hand 1, calcium-binding site

1 reference

pleckstrin homology domain

1 reference

Phosphatidylinositol-specific phospholipase C, X domain

1 reference

Phospholipase C, phosphatidylinositol-specific, Y domain

1 reference

SH2 domain

1 reference

PLC-gamma, N-terminal SH2 domain

1 reference

PLC-gamma, C-terminal SH2 domain

1 reference

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain

1 reference