(Q28558105)

http://www.ebi.ac.uk/interpro/protein/P22288

GTP cyclohydrolase I domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GTP cyclohydrolase I, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

GTP cyclohydrolase I activity

10 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Purification and characterization of rat liver GTP cyclohydrolase I. Cooperative binding of GTP to the enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

1 reference

14 February 2019

Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

4 references

14 February 2019

Identification of a rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Purification and characterization of rat liver GTP cyclohydrolase I. Cooperative binding of GTP to the enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

GTP-dependent protein binding

1 reference

14 February 2019

Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

translation initiation factor binding

IPI

1 reference

14 February 2019

The protein partners of GTP cyclohydrolase I in rat organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

protein homodimerization activity

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

mitogen-activated protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

protein-containing complex

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

tetrahydrobiopterin biosynthetic process

biological process

4 references

14 February 2019

Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

regulation of blood pressure

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

positive regulation of heart rate

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

regulation of lung blood pressure

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

response to lipopolysaccharide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

response to interferon-gamma

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

response to tumor necrosis factor

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

7,8-dihydroneopterin 3'-triphosphate biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

1 reference

14 February 2019

GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

dopamine biosynthetic process

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

pteridine-containing compound biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

negative regulation of blood pressure

1 reference

14 February 2019

GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

tetrahydrofolate biosynthetic process

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

1 reference

14 February 2019

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

neuromuscular process controlling posture

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

positive regulation of nitric-oxide synthase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

dihydrobiopterin metabolic process

3 references

14 February 2019

Purification and characterization of rat liver GTP cyclohydrolase I. Cooperative binding of GTP to the enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

protein homooligomerization

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Purification and characterization of rat liver GTP cyclohydrolase I. Cooperative binding of GTP to the enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

protein heterooligomerization

3 references

14 February 2019

Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

protein-containing complex assembly

3 references

14 February 2019

Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

14 February 2019

Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

regulation of removal of superoxide radicals

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288

GTP cyclohydrolase I, conserved site

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22288

GTP cyclohydrolase I domain

1 reference

stated in

InterPro Release 71.0