(Q28561024)

English

Egl-9 family hypoxia-inducible factor 1

mammalian protein found in Rattus norvegicus

HIF-prolyl hydroxylase 2
egl nine homolog 1
LOW QUALITY PROTEIN: egl nine homolog 1
prolyl hydroxylase domain-containing protein 2
Egln1
hypoxia-inducible factor prolyl hydroxylase 2

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Statements

1 reference

17 November 2021

1 reference

19 January 2017

Prolyl 4-hydroxylase, alpha subunit, protein family

1 reference

based on heuristic

inferred from protein domain or family

Oxoglutarate/iron-dependent dioxygenase family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

17 November 2021

1 reference

17 November 2021

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

determination method

ISS

oxidoreductase activity

determination method

IEA

2 references

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

2 references

L-ascorbic acid binding

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

1 reference

14 February 2019

Beta-cell alpha-ketoglutarate hydroxylases may acutely participate in insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

1 reference

14 February 2019

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

determination method

IDA

peptidyl-proline hydroxylation

1 reference

14 February 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

determination method

IEA

positive regulation of apoptotic process

1 reference

14 February 2019

Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

determination method

IDA

negative regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

determination method

IDA

regulation of angiogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

determination method

ISS

negative regulation of cyclic-nucleotide phosphodiesterase activity

determination method

IDA

IMP

2 references

response to nitric oxide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

determination method

ISS

positive regulation of neuron death

1 reference

14 February 2019

Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

determination method

IDA

negative regulation of CAMKK-AMPK signaling cascade

1 reference

14 February 2019

Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P59722

determination method

IMP

has part(s)

Prolyl 4-hydroxylase, alpha subunit

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P59722

Oxoglutarate/iron-dependent dioxygenase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P59722

Identifiers

1 reference

7 September 2021

1 reference

17 November 2021

1 reference

(Q28561024)

Egl-9 family hypoxia-inducible factor 1

Statements

Identifiers

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