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(Q28562845)
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Slit guidance ligand 1
mammalian protein found in Rattus norvegicus
slit homolog 1 protein
multiple EGF-like domains protein 4
multiple epidermal growth factor-like domains protein 4
multiple epidermal growth factor-like domains 4
Slit1
slit-1
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
O88279
subclass of
protein
1 reference
stated in
UniProt
retrieved
19 January 2017
UniProt protein ID
O88279
part of
Leucine-rich repeat domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
Concanavalin A-like lectin/glucanase domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
Growth factor receptor cysteine-rich domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
Laminin G domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Follistatin-like, N-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Leucine-rich repeat N-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Cystine knot, C-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
EGF-like calcium-binding domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Cysteine-rich flanking region, C-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
EGF-like domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Leucine-rich repeat, typical subtype, protein family
1 reference
based on heuristic
inferred from protein domain or family
EGF-like, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
Leucine-rich repeat, protein family
1 reference
based on heuristic
inferred from protein domain or family
EGF-like calcium-binding, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
brown rat
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
O88279
encoded by
Slit1
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
O88279
molecular function
calcium ion binding
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IEA
protein binding
determination method
IPI
1 reference
retrieved
9 May 2019
stated in
Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IPI
heparan sulfate proteoglycan binding
determination method
IDA
1 reference
retrieved
9 May 2019
stated in
Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IDA
heparin binding
determination method
IBA
1 reference
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IBA
Roundabout binding
determination method
IBA
1 reference
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IBA
cell component
extracellular region
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O88279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IEA
extracellular space
determination method
IDA
1 reference
retrieved
14 February 2019
stated in
Expression and function of Slit1alpha, a novel alternative splicing product for slit1
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IDA
extracellular space
determination method
IBA
IDA
2 references
retrieved
9 May 2019
stated in
Expression and function of Slit1alpha, a novel alternative splicing product for slit1
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IBA
biological process
multicellular organism development
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O88279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IEA
nervous system development
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O88279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IEA
brain development
determination method
IEP
1 reference
retrieved
9 May 2019
stated in
Spatiotemporal expression patterns of slit and robo genes in the rat brain
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IEP
spinal cord development
determination method
IEP
1 reference
retrieved
9 May 2019
stated in
Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IEP
cell differentiation
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O88279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IEA
negative regulation of axon extension involved in axon guidance
determination method
IDA
1 reference
retrieved
9 May 2019
stated in
Expression and function of Slit1alpha, a novel alternative splicing product for slit1
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IDA
negative regulation of synapse assembly
determination method
ISS
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O88279
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
ISS
axon guidance
determination method
IBA
1 reference
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IBA
negative chemotaxis
determination method
IBA
1 reference
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88279
determination method
IBA
has part(s)
leucine-rich repeat, typical subtype
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
follistatin-like, N-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
leucine-rich repeat N-terminal domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
cysteine-rich flanking region, C-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
EGF-like, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
EGF-like calcium-binding domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
EGF-like domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
EGF-like calcium-binding, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
EGF-type aspartate/asparagine hydroxylation site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
Leucine-rich repeat
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
Cystine knot, C-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
Laminin G domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O88279
Identifiers
RefSeq protein ID
NP_075242
1 reference
stated in
NCBI Gene
retrieved
7 September 2021
Entrez Gene ID
65047
UniProt protein ID
O88279
1 reference
stated in
UniProt
retrieved
17 November 2021
UniProt protein ID
O88279
Ensembl protein ID
ENSRNOP00000035315
1 reference
stated in
ensembl Release 104
Ensembl protein ID
ENSRNOP00000035315
ENSRNOP00000035180
1 reference
stated in
ensembl Release 104
Ensembl protein ID
ENSRNOP00000035180
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