(Q28566169)

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Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation

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scholarly article

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31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15096502%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation (English)

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15096502%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

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27 December 2019

Marie-Helene Lafage-Proust

4

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27 December 2019

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Alain Guignandon

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31 January 2017

Europe PubMed Central

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27 December 2019

Laurence Vico

3

2 references

31 January 2017

Europe PubMed Central

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27 December 2019

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19 April 2004

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27 December 2019

Journal of Biological Chemistry

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31 January 2017

Europe PubMed Central

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27 December 2019

279

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31 January 2017

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27 December 2019

29

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31 January 2017

Europe PubMed Central

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27 December 2019

30588-30599

1 reference

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27 December 2019

Mechanically strained cells of the osteoblast lineage organize their extracellular matrix through unique sites of alphavbeta3-integrin expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

NO inhibits stretch-induced MAPK activity by cytoskeletal disruption.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

The mode of mechanical integrin stressing controls intracellular signaling in osteoblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Characteristics of in vitro osteoblastic cell loading models

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Mechanical stressing of integrin receptors induces enhanced tyrosine phosphorylation of cytoskeletally anchored proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Biological aspects of signal transduction by cell adhesion receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

FAK integrates growth-factor and integrin signals to promote cell migration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Signaling through focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Fluoroaluminate induces activation and association of Src and Pyk2 tyrosine kinases in osteoblastic MC3T3-E1 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Parathyroid hormone-responsive clonal cell lines from rat osteosarcoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Differential roles of extracellular signal-regulated kinase-1/2 and p38(MAPK) in interleukin-1beta- and tumor necrosis factor-alpha-induced low density lipoprotein receptor expression in HepG2 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent tyrosine kinase in rat liver epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Src family kinases are required for integrin-mediated but not for G protein-coupled receptor stimulation of focal adhesion kinase autophosphorylation at Tyr-397.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Activation of Cell Adhesion Kinase β by Mechanical Stretch in Vascular Smooth Muscle Cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Mechanotransduction in endothelial cells: temporal signaling events in response to shear stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Mechanical stress mechanisms and the cell. An endothelial paradigm

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Leptin mediates a proliferative response in human MCF7 breast cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Enhancement of erythropoietin-stimulated cell proliferation by Anandamide correlates with increased activation of the mitogen-activated protein kinases ERK1 and ERK2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

PYK2 autophosphorylation, but not kinase activity, is necessary for adhesion-induced association with c-Src, osteoclast spreading, and bone resorption

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Physiological mechanism-based analysis of dose-dependent gastrointestinal absorption of L-carnitine in rats.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Assembly and mechanosensory function of focal contacts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Focal adhesion kinase is involved in mechanosensing during fibroblast migration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Focal adhesion kinase promotes phospholipase C-gamma1 activity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Association of focal adhesion kinase with Grb7 and its role in cell migration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Interactions between two cytoskeleton-associated tyrosine kinases: calcium-dependent tyrosine kinase and focal adhesion tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313244200

21 January 2018

Identifiers

10.1074/JBC.M313244200

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15096502%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15096502%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

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