(Q28566776)

English

Central administration of a cytochrome P450-7B product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats

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scholarly article

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Central administration of a cytochrome P450-7B product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats (English)

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

7alpha-Hydroxypregnenolone

1 reference

ChEBI release 2020-05-28

1 reference

based on heuristic

inferred from title

author name string

June Noble

2

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Mags Graham

3

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Joyce L W Yau

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Jonathan R Seckl

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

language of work or name

0 references

publication date

1 October 2006

1 reference

Europe PubMed Central

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21 December 2019

Journal of Neuroscience

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

26

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

43

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

11034-11040

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Exposing rats to a predator impairs spatial working memory in the radial arm water maze.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 7alpha-hydroxysteroids produced in human tonsils enhance the immune response to tetanus toxoid and Bordetella pertussis antigens

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolonged intracerebroventricular infusion of neurosteroids affects cognitive performances in the mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

7-Hydroxydehydroepiandrosterone--a natural antiglucocorticoid and a candidate for steroid replacement therapy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroid hydroxylase CYP7B: vivid reporter activity in dentate gyrus of gene-targeted mice and abolition of a widespread pathway of steroid and oxysterol hydroxylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ontogeny of the neurosteroid enzyme Cyp7b in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroid 7-hydroxylation products in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Old rats remember old tricks; memories of the water maze persist for 12 months.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and Delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

7-Hydroxylated epiandrosterone (7-OH-EPIA) reduces ischaemia-induced neuronal damage both in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroactive steroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Individual differences in cognitive aging: implication of pregnenolone sulfate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroid metabolism. 7 alpha-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pregnenolone sulfate enhances long-term potentiation in CA1 in rat hippocampus slices through the modulation of N-methyl-D-aspartate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into the role of neuroactive steroids in cognitive aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dehydroepiandrosterone and its 7-hydroxylated metabolites do not interfere with the transactivation and cellular trafficking of the glucocorticoid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of neuroactive steroids and their precursors and metabolites in adult male rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoreactive cytochrome P-45017 in rat and guineapig gonads, adrenal glands and brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection from glucocorticoid induced thymic involution by dehydroepiandrosterone

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

11 beta-hydroxysteroid dehydrogenase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus, and cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dehydroepiandrosterone and its sulfate enhance memory retention in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dehydroepiandrosterone sulfate improves memory in aging mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel cytochrome P450 expressed primarily in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroids: biosynthesis and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7 alpha-hydroxylation in mouse tissues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

11beta-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Facilitation of cognitive performance in aged rats by past experience depends on the type of information processing involved: a combined cross-sectional and longitudinal study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of the immune response by DHEA and its metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/17065445

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3189-06.2006

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17065445%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

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