(Q44390926)

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In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and Delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patients.

scientific article published in April 2003

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12676372%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

In vitro metabolism of dehydroepiandrosterone (DHEA) to 7alpha-hydroxy-DHEA and Delta5-androstene-3beta,17beta-diol in specific regions of the aging brain from Alzheimer's and non-demented patients (English)

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2 November 2019

Alzheimer's disease

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7α-hydroxydehydroepiandrosterone

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ChEBI release 2020-05-28

8

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2 November 2019

Étienne-Émile Baulieu

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Etienne Emile Baulieu

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2 November 2019

Michael Schumacher

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Michael Schumacher

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2 November 2019

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Sébastien Weill-Engerer

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2 November 2019

Jean Philippe David

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2 November 2019

Véronique Sazdovitch

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2 November 2019

Philippe Liere

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2 November 2019

André Delacourte

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2 November 2019

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1 April 2003

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2 November 2019

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2 November 2019

969

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2 November 2019

1-2

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2 November 2019

117-125

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2 November 2019

Neurosteroid metabolism. 7 alpha-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes

1 reference

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7 January 2021

Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density.

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7 January 2021

Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats

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7 January 2021

Dehydroepiandrosterone supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretion

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7 January 2021

Increased total 7 alpha-hydroxy-dehydroepiandrosterone in serum of patients with Alzheimer's disease

1 reference

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7 January 2021

Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage

1 reference

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7 January 2021

Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue

1 reference

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7 January 2021

Neurosteroids: beginning of the story

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7 January 2021

Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections

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7 January 2021

Staging of Alzheimer's disease-related neurofibrillary changes

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7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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7 January 2021

Dehydroepiandrosterone protects hippocampal neurons against neurotoxin-induced cell death: mechanism of action

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7 January 2021

Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development

1 reference

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7 January 2021

Neurosteroids: biosynthesis and function of these novel neuromodulators

1 reference

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7 January 2021

Characterization and measurement of dehydroepiandrosterone sulfate in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2803%2902288-1

7 January 2021

Pregnenolone and its sulfate ester in the rat brain

1 reference

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7 January 2021

The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease

1 reference

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7 January 2021

The enhancement of hippocampal primed burst potentiation by dehydroepiandrosterone sulfate (DHEAS) is blocked by psychological stress.

1 reference

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7 January 2021

Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7 alpha-hydroxylation in mouse tissues.

1 reference

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7 January 2021

Dehydroepiandrosterone 7alpha- and 7beta-hydroxylation in mouse brain microsomes. Effects of cytochrome P450 inhibitors and structure-specific inhibition by steroid hormones

1 reference

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7 January 2021

Neurosteroids and behavior

1 reference

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7 January 2021

Dehydroepiandrosterone sulfate improves memory in aging mice.

1 reference

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7 January 2021

Dehydroepiandrosterone (DHEA) stimulates neurogenesis in the hippocampus of the rat, promotes survival of newly formed neurons and prevents corticosterone-induced suppression

1 reference

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7 January 2021

In vitro transformation of dehydroepiandrosterone or its sulphate into androstenediol or its sulphate by rat brain and blood preparations

1 reference

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7 January 2021

Metabolism of free and sulfoconjugated DHEA in brain tissue in vivo and in vitro.

1 reference

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7 January 2021

Modulation of native and recombinant GABAA receptors by endogenous and synthetic neuroactive steroids

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7 January 2021

Dehydroepiandrosterone sulfate: a biomarker of primate aging slowed by calorie restriction

1 reference

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7 January 2021

Steroid and sterol 7-hydroxylation: ancient pathways

1 reference

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7 January 2021

Age and sex differences of dehydroepiandrosterone sulfate (DHEAS) and cortisol (CRT) plasma levels in normal controls and Alzheimer's disease (AD).

1 reference

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7 January 2021

Dehydroepiandrosterone (DHEA) reduces neuronal injury in a rat model of global cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2803%2902288-1

7 January 2021

Validation of an analytical procedure to measure trace amounts of neurosteroids in brain tissue by gas chromatography-mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2803%2902288-1

7 January 2021

Immune up-regulation and tumor apoptosis by androstene steroids

1 reference

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7 January 2021

Neuroprotection by dehydroepiandrosterone-sulfate: role of an NFkappaB-like factor

1 reference

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7 January 2021

Sigma1 (sigma 1) receptor agonists and neurosteroids attenuate B25-35-amyloid peptide-induced amnesia in mice through a common mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2803%2902288-1

7 January 2021

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

1 reference

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7 January 2021

Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice

1 reference

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7 January 2021

Neurosteroid 7-hydroxylation products in the brain

1 reference

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7 January 2021

Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2803%2902288-1

7 January 2021

17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes

1 reference

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7 January 2021

Dehydroepiandrosterone and the relationship with aging and memory: a possible link with protein kinase C functional machinery

1 reference

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7 January 2021

Neuro-steroids: 3 beta-hydroxy-delta 5-derivatives in rat and monkey brain

1 reference

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7 January 2021

Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone

1 reference

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7 January 2021

Neuropsychopharmacological properties of neuroactive steroids

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7 January 2021

Steroid synthesis and metabolism in the nervous system: trophic and protective effects

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7 January 2021

Expression of the 17beta-hydroxysteroid dehydrogenase type 5 mRNA in the human brain

1 reference

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7 January 2021

Characterization of the dehydroepiandrosterone (DHEA) metabolism via oxysterol 7alpha-hydroxylase and 17-ketosteroid reductase activity in the human brain

1 reference

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7 January 2021

Neurosteroid metabolism in the human brain

1 reference

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7 January 2021

Expression of 17beta-hydroxysteroid dehydrogenase types 1, 2, 3 and 4 in the human temporal lobe.

1 reference

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7 January 2021

Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging

1 reference

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7 January 2021

Cells in human postmortem brain tissue slices remain alive for several weeks in culture

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7 January 2021

Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients.

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7 January 2021

Actions of dehydroepiandrosterone and its sulfate in the central nervous system: effects on cognition and emotion in animals and humans

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7 January 2021

Dehydroepiandrosterone replacement in elderly individuals: still waiting for the proof of beneficial effects on mood or memory.

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7 January 2021

Neuroblastoma and Alzheimer's disease brain cells contain aromatase activity

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7 January 2021

Serum dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) in Alzheimer's disease and in cerebrovascular dementia.

1 reference

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7 January 2021

Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing ways

1 reference

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7 January 2021

Identifiers

10.1016/S0006-8993(03)02288-1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12676372%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12676372%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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