(Q28570444)

31 January 2017

title

Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions (English)

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31 January 2017

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Eun Suk Song

1

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31 January 2017

Abigail Daily

2

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31 January 2017

Michael G. Fried

3

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31 January 2017

Maria Aparecida Juliano

4

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31 January 2017

Luiz Juliano

5

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31 January 2017

Louis B. Hersh

6

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31 January 2017

language of work or name

English

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publication date

6 May 2005

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Journal of Biological Chemistry

31 January 2017

published in

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31 January 2017

volume

280

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31 January 2017

issue

18

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31 January 2017

page(s)

17701–17706

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

31 January 2017

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

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Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

21 January 2018

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Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.

21 January 2018

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Clearing amyloid through the blood-brain barrier

21 January 2018

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Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells

21 January 2018

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Peptidases, proteases and amyloid beta-peptide catabolism

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Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

21 January 2018

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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

21 January 2018

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Neprilysin regulates amyloid Beta peptide levels

21 January 2018

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Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

21 January 2018

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

21 January 2018

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Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

21 January 2018

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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

21 January 2018

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Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease

21 January 2018

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Susceptibility locus for Alzheimer's disease on chromosome 10.

21 January 2018

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Insulin degradation: progress and potential

21 January 2018

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Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling

21 January 2018

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Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

21 January 2018

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Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

21 January 2018

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Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme

21 January 2018

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Insulin-degrading enzyme: embarking on amyloid destruction.

21 January 2018

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Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development.

21 January 2018

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Prediction of protein secondary structure at better than 70% accuracy

21 January 2018

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Analysis of data from the analytical ultracentrifuge by nonlinear least-squares techniques

21 January 2018

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Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein.

21 January 2018

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ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety

21 January 2018

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Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296

21 January 2018

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Identification of glutamate residues essential for catalytic activity and zinc coordination in aminopeptidase A.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M501896200

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31 January 2017

1 reference