(Q28574540)

English

Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity

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scholarly article

1 reference

PubMed publication ID

31 January 2017

Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity (English)

1 reference

PubMed publication ID

31 January 2017

author name string

Md Nawajes A. Mandal

1

1 reference

PubMed publication ID

31 January 2017

Gennadiy P. Moiseyev

2

1 reference

PubMed publication ID

31 January 2017

Michael H. Elliott

3

1 reference

PubMed publication ID

31 January 2017

Anne Kasus-Jacobi

4

1 reference

PubMed publication ID

31 January 2017

Xiaoman Li

5

1 reference

PubMed publication ID

31 January 2017

Hui Chen

6

1 reference

PubMed publication ID

31 January 2017

Lixin Zheng

7

1 reference

PubMed publication ID

31 January 2017

Olga Nikolaeva

8

1 reference

PubMed publication ID

31 January 2017

Robert A. Floyd

9

1 reference

PubMed publication ID

31 January 2017

Jian-Xing Ma

10

1 reference

PubMed publication ID

31 January 2017

Robert E. Anderson

11

1 reference

PubMed publication ID

31 January 2017

language of work or name

0 references

publication date

16 September 2011

1 reference

PubMed publication ID

31 January 2017

Journal of Biological Chemistry

1 reference

PubMed publication ID

31 January 2017

286

1 reference

PubMed publication ID

31 January 2017

37

1 reference

PubMed publication ID

31 January 2017

32491–32501

1 reference

PubMed publication ID

31 January 2017

RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

19 March 2017

Crystal structure of native RPE65, the retinoid isomerase of the visual cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

19 March 2017

Delayed loss of cone and remaining rod photoreceptor cells due to impairment of choroidal circulation after acute light exposure in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

19 March 2017

RPE65 is the isomerohydrolase in the retinoid visual cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

19 March 2017

Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

19 March 2017

Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

19 March 2017

Rhodopsin-mediated blue-light damage to the rat retina: effect of photoreversal of bleaching

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

19 March 2017

Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

19 March 2017

Mutations in the RPE65 gene in patients with autosomal recessive retinitis pigmentosa or leber congenital amaurosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

19 March 2017

Mutations in RPE65 cause autosomal recessive childhood-onset severe retinal dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

19 March 2017

Mutations in RPE65 cause Leber's congenital amaurosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

19 March 2017

Aromatic lipophilic spin traps effectively inhibit RPE65 isomerohydrolase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

The cone-specific visual cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Pharmacologic treatment of atrophic age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Retinal light damage: mechanisms and protection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

RPE65 from cone-dominant chicken is a more efficient isomerohydrolase compared with that from rod-dominant species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

The specific binding of retinoic acid to RPE65 and approaches to the treatment of macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Current concepts in the pathogenesis of age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Genetics and phenotypes of RPE65 mutations in inherited retinal degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Apoptotic cell death in retinal degenerations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Protection from cerebral ischemic injury in gerbils with the spin trap agent N-tert-butyl-alpha-phenylnitrone (PBN).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

29 September 2017

Investigating the free radical trapping ability of NXY-059, S-PBN and PBN.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

3 June 2018

Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

3 June 2018

Antioxidant treatment with phenyl-alpha-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

3 June 2018

Endotoxin-induced mortality in rats is reduced by nitrones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

3 June 2018

Protection by dimethylthiourea against retinal light damage in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

3 June 2018

Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.255877

21 January 2018

Mechanism of protection from light-induced retinal degeneration by the synthetic antioxidant phenyl-N-tert-butylnitrone

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.255877

21 January 2018

Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone (PBN).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.255877

21 January 2018

Evidence for two apoptotic pathways in light-induced retinal degeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.255877

21 January 2018

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.255877

21 January 2018

Retinyl esters are the substrate for isomerohydrolase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.255877

21 January 2018

Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.255877

21 January 2018

The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.255877

21 January 2018

Free radical trap phenyl-N-tert-butylnitrone protects against light damage but does not rescue P23H and S334ter rhodopsin transgenic rats from inherited retinal degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

27 November 2018

Identification of the RPE65 protein in mammalian cone photoreceptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

27 November 2018

Prevention of photoreceptor apoptosis by activation of the glucocorticoid receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

27 November 2018

Systemic administration of phenyl-N-tert-butylnitrone protects the retina from light damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

27 November 2018

The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173208

27 November 2018

Spin trapping agent, phenyl N-tert-butyl nitrone, inhibits induction of nitric oxide synthase in endotoxin-induced shock in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinopathy induced in mice by targeted disruption of the rhodopsin gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spin trapping agent phenyl N-tert-butylnitrone protects against the onset of drug-induced insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The melatonin antagonist luzindole protects retinal photoreceptors from light damage in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cytokines and activation of transcription factors in lipopolysaccharide-administered rats and their inhibition by phenyl N-tert-butylnitrone (PBN)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EPR spin trapping detection of carbon-centered carotenoid and beta-ionone radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset severe rod-cone dystrophy in young children with RPE65 mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinal damage by light in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemistry of visual pigments. I. Purification and properties of bovine rhodopsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin A Deficiency Effect on Retina: Dependence on Light

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Irreversible Effects of Visible Light on the Retina: Role of Vitamin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protective effect of ascorbate in retinal light damage of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenyl-T-butyl-nitrone is active against traumatic shock in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid peroxidation in rod outer segments. Role of hydroxyl radical and lipid hydroperoxides

1 reference

https://pubmed.ncbi.nlm.nih.gov/21785167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.255877

1 reference

PubMed publication ID

31 January 2017

PMC publication ID

0 references

PubMed publication ID

1 reference

PubMed publication ID

31 January 2017

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