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The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2
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scholarly article
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PubMed
PubMed ID
12049732
retrieved
31 January 2017
title
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2
(English)
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PubMed
PubMed ID
12049732
retrieved
31 January 2017
main subject
protein ubiquitination
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inferred from title
author name string
Zhimin Lu
series ordinal
1
1 reference
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PubMed
PubMed ID
12049732
retrieved
31 January 2017
Shuichan Xu
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
12049732
retrieved
31 January 2017
Claudio Joazeiro
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
12049732
retrieved
31 January 2017
Melanie H. Cobb
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
12049732
retrieved
31 January 2017
Tony Hunter
series ordinal
5
1 reference
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PubMed
PubMed ID
12049732
retrieved
31 January 2017
language of work or name
English
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publication date
1 May 2002
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PubMed
PubMed ID
12049732
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31 January 2017
published in
Molecular Cell
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PubMed
PubMed ID
12049732
retrieved
31 January 2017
volume
9
1 reference
stated in
PubMed
PubMed ID
12049732
retrieved
31 January 2017
issue
5
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stated in
PubMed
PubMed ID
12049732
retrieved
31 January 2017
page(s)
945–956
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stated in
PubMed
PubMed ID
12049732
retrieved
31 January 2017
cites work
Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family
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The PHD finger: implications for chromatin-mediated transcriptional regulation
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Crossref
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7 January 2021
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The U box is a modified RING finger — a common domain in ubiquitination
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reference URL
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7 January 2021
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The RING finger domain: a recent example of a sequence-structure family
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reference URL
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7 January 2021
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Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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inferred from DOI database lookup
Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains
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reference URL
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7 January 2021
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Mammalian MAP kinase signalling cascades
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7 January 2021
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MAP kinase pathways
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7 January 2021
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A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition
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reference URL
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7 January 2021
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Serine/threonine protein kinases and apoptosis.
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7 January 2021
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Signal transduction by the JNK group of MAP kinases
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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain
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reference URL
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7 January 2021
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B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway
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7 January 2021
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The RING finger. A novel protein sequence motif related to the zinc finger.
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7 January 2021
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Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain
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reference URL
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7 January 2021
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Ubiquitin-dependent degradation of active Src.
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7 January 2021
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Ubiquitin-mediated degradation of active Src tyrosine kinase
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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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U box proteins as a new family of ubiquitin-protein ligases
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitin-dependent protein degradation
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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inferred from DOI database lookup
MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly
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Membrane-bound human 3beta-hydroxysteroid dehydrogenase: overexpression with His-tag using a baculovirus system and single-step purification
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7 January 2021
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The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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Modifying chromatin and concepts of cancer
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7 January 2021
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Biochemistry. Ubiquitination--more than two to tango
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7 January 2021
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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
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A proteolytic pathway that recognizes ubiquitin as a degradation signal
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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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MEKK1 binds raf-1 and the ERK2 cascade components
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases
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7 January 2021
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A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.
1 reference
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Crossref
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7 January 2021
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Characterization of apoptosis induced by sorbitol: a unique system for the detection of antiapoptotic activities of viruses.
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7 January 2021
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A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
1 reference
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https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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The APC11 RING-H2 finger mediates E2-dependent ubiquitination
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7 January 2021
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Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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inferred from DOI database lookup
A novel human gene, WSTF, is deleted in Williams syndrome
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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Activation of protein kinase C triggers its ubiquitination and degradation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
inferred from DOI database lookup
MEK inhibition enhances paclitaxel-induced tumor apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: altered sub-cellular distribution of mutants lacking the PHD zinc fingers
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
inferred from DOI database lookup
The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a novel mutation in the autoimmune regulator (AIRE-1) gene in a French family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
inferred from DOI database lookup
Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
inferred from DOI database lookup
A conserved docking motif in MAP kinases common to substrates, activators and regulators
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
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MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
inferred from DOI database lookup
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
inferred from DOI database lookup
MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
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Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
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Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1097-2765%2802%2900519-1
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7 January 2021
based on heuristic
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Identifiers
DOI
10.1016/S1097-2765(02)00519-1
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3938557
OpenCitations bibliographic resource ID
3938557
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3938557
PubMed ID
12049732
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3938557
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