(Q28580875)

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LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism

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scholarly article

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PubMed publication ID

31 January 2017

LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism (English)

1 reference

PubMed publication ID

31 January 2017

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author name string

Haipeng Sun

1

1 reference

PubMed publication ID

31 January 2017

Beibei Xu

2

1 reference

PubMed publication ID

31 January 2017

Elena Sheveleva

3

1 reference

PubMed publication ID

31 January 2017

Qin M. Chen

4

1 reference

PubMed publication ID

31 January 2017

publication date

1 October 2008

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PubMed publication ID

31 January 2017

Toxicology and Applied Pharmacology

1 reference

PubMed publication ID

31 January 2017

232

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PubMed publication ID

31 January 2017

1

1 reference

PubMed publication ID

31 January 2017

25–32

1 reference

PubMed publication ID

31 January 2017

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

1 reference

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CREB-dependent cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression is mediated by protein kinase C and calcium

1 reference

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17 March 2017

Hypoxia-reoxygenation-induced apoptosis in cultured neonatal rat cardiomyocyets and the protective effect of prostaglandin E

1 reference

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17 March 2017

Corticosteroids inhibit cell death induced by doxorubicin in cardiomyocytes: induction of antiapoptosis, antioxidant, and detoxification genes

1 reference

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17 March 2017

Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning

1 reference

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17 March 2017

Synthesis and function of 3-phosphorylated inositol lipids

1 reference

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17 March 2017

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

2 references

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17 March 2017

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29 September 2017

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

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Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

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17 March 2017

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

1 reference

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17 March 2017

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

1 reference

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17 March 2017

Cyclooxygenases: structural, cellular, and molecular biology

1 reference

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7 April 2017

Prostaglandin E2 drives cyclooxygenase-2 expression via cyclic AMP response element activation in human pancreatic cancer cells

1 reference

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29 September 2017

Role of the protein kinase C-epsilon-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning

1 reference

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29 September 2017

Glucocorticoids: effects on gene transcription

1 reference

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29 September 2017

LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway

1 reference

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29 September 2017

Dexamethasone and cardiac potassium currents in the diabetic rat

1 reference

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29 September 2017

p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression.

1 reference

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29 September 2017

LY294002 inhibits LPS-induced NO production through a inhibition of NF-kappaB activation: independent mechanism of phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148022

29 September 2017

High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148022

29 September 2017

Inhibition of L-type Cav1.2 Ca2+ channels by 2,(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-dimethyl-aminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide (Go6983).

1 reference

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29 September 2017

The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148022

29 September 2017

Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4148022

29 September 2017

The phosphatidylinositol 3-kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17beta-estradiol-induced transcriptional activity of an estrogen sensitive reporter gene

1 reference

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29 September 2017

The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism

1 reference

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29 September 2017

Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase

1 reference

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29 September 2017

Cyclooxygenase-2: a therapeutic target

1 reference

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29 September 2017

Cyclooxygenase-2--10 years later

1 reference

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29 September 2017

Roles of Akt and glycogen synthase kinase 3beta in the ultraviolet B induction of cyclooxygenase-2 transcription in human keratinocytes.

1 reference

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29 September 2017

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

1 reference

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29 September 2017

Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin

1 reference

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29 September 2017

Effects of phosphatidylinositol kinase inhibitors on the activation of the store-operated calcium current ICRAC in RBL-1 cells

1 reference

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3 June 2018

Corticosterone impairs hippocampal neuronal calcium regulation--possible mediating mechanisms

1 reference

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3 June 2018

Stretch induction of cyclooxygenase-2 expression in human urothelial cells is calcium- and protein kinase C zeta-dependent

1 reference

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27 November 2018

Transient-outward K+ channel inhibition facilitates L-type Ca2+ current in heart

1 reference

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27 November 2018

LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms

1 reference

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27 November 2018

Inhibition of p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase decreases UVB-induced activator protein-1 and cyclooxygenase-2 in a SKH-1 hairless mouse model

1 reference

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Prostacyclin attenuates oxidative damage of myocytes by opening mitochondrial ATP-sensitive K+ channels via the EP3 receptor

1 reference

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27 November 2018

Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts

1 reference

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27 November 2018

Extracellular calcium induces COX-2 in osteoblasts via a PKA pathway

1 reference

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27 November 2018

The phosphoinositide 3-kinase inhibitor LY294002 enhances cardiac myocyte contractility via a direct inhibition of Ik,slow currents

1 reference

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27 November 2018

c-Fos phosphorylation induced by H2O2 prevents proteasomal degradation of c-Fos in cardiomyocytes

1 reference

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27 November 2018

Prostaglandin E2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP4.

1 reference

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27 November 2018

LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism

1 reference

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27 November 2018

High-density lipoproteins protect isolated rat hearts from ischemia-reperfusion injury by reducing cardiac tumor necrosis factor-alpha content and enhancing prostaglandin release

1 reference

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27 November 2018

LY294002, but not wortmannin, increases intracellular calcium and inhibits calcium transients in bovine and human airway smooth muscle cells

1 reference

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27 November 2018

Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice

1 reference

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27 November 2018

Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase

1 reference

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27 November 2018

Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning.

1 reference

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27 November 2018

Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes

1 reference

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Glucocorticoid modulation of calcium currents in growth hormone 3 cells

1 reference

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27 November 2018

Dexamethasone and stress upregulate Kv1.5 K+ channel gene expression in rat ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18657281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/18657281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of K+ channel modulators on the relationship between action potential duration and Ca2+ transients in single ventricular myocytes of the guinea pig

1 reference

https://pubmed.ncbi.nlm.nih.gov/18657281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

K(+) channel inhibition, calcium signaling, and vasomotor tone in canine pulmonary artery smooth muscle

1 reference

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12 December 2020

based on heuristic

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Translational control of nrf2 protein in activation of antioxidant response by oxidants

1 reference

https://pubmed.ncbi.nlm.nih.gov/18657281

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.TAAP.2008.05.024

1 reference

PubMed publication ID

31 January 2017

PMC publication ID

0 references

PubMed publication ID

1 reference

PubMed publication ID

31 January 2017

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