(Q28586335)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14673138%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

title

Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model (English)

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14673138%20AND%20SRC:MED&resulttype=core&format=json

Peroxisomal biogenesis factor 2

22 December 2019

main subject

knockout mouse

0 references

1 reference

GOA release 2020-03-11

author

Werner J Kovacs

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14673138%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

author name string

Janis E Shackelford

2

1 reference

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22 December 2019

Khanichi N Tape

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14673138%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Michael J Richards

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14673138%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Phyllis L Faust

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14673138%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

Steven J Fliesler

6

1 reference

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22 December 2019

Skaidrite K Krisans

7

1 reference

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22 December 2019

language of work or name

English

0 references

publication date

1 January 2004

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14673138%20AND%20SRC:MED&resulttype=core&format=json

Molecular and Cellular Biology

22 December 2019

published in

2 references

31 January 2017

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22 December 2019

volume

24

2 references

31 January 2017

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22 December 2019

page(s)

1-13

1 reference

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22 December 2019

issue

1

2 references

31 January 2017

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describes a project that uses

22 December 2019

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC303355/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Abnormal cerebellar histogenesis in PEX2 Zellweger mice reflects multiple neuronal defects induced by peroxisome deficiency

1 reference

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Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

17 March 2017

1 reference

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Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance

17 March 2017

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The enzymes, regulation, and genetics of bile acid synthesis

17 March 2017

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Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

17 March 2017

1 reference

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Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol

17 March 2017

1 reference

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Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

17 March 2017

1 reference

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

17 March 2017

1 reference

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Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis

17 March 2017

1 reference

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Mitochondrial alterations caused by defective peroxisomal biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout mouse)

17 March 2017

1 reference

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

17 March 2017

1 reference

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

17 March 2017

1 reference

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ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

17 March 2017

1 reference

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Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism

17 March 2017

1 reference

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A mouse model for Zellweger syndrome

17 March 2017

1 reference

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Farnesyl-diphosphate synthase is localized in peroxisomes

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Mevalonate kinase is predominantly localized in peroxisomes and is defective in patients with peroxisome deficiency disorders

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Evaluation of methods for the measurement of low-density lipoprotein cholesterol.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Central role of peroxisomes in isoprenoid biosynthesis

29 September 2017

1 reference

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Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home

29 September 2017

1 reference

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BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis

29 September 2017

1 reference

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ABCA1. The gatekeeper for eliminating excess tissue cholesterol.

29 September 2017

1 reference

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The peroxisome deficient PEX2 Zellweger mouse: pathologic and biochemical correlates of lipid dysfunction.

29 September 2017

1 reference

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Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system

29 September 2017

1 reference

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The origins and roles of cholesterol and fatty acids in the fetus

29 September 2017

1 reference

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An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

29 September 2017

1 reference

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Cholesterol synthesis and accretion within various tissues of the fetal and neonatal rat.

29 September 2017

1 reference

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Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder

29 September 2017

1 reference

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Characterization of UT2 cells. The induction of peroxisomal 3-hydroxy-3-methylglutaryl-coenzyme a reductase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA.

29 September 2017

1 reference

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Cholesterol metabolism in cells with different peroxisomal defects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

How proteins penetrate peroxisomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Complete nucleotide sequence of cDNA and predicted amino acid sequence of rat acyl-CoA oxidase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Normal cholesterol synthesis in human cells requires functional peroxisomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

29 September 2017

Bile acid biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Mechanism of degradation of the steroid side chain in the formation of bile acids

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Isoprenoid biosynthesis is not compromised in a Zellweger syndrome mouse model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Subcellular localization of squalene synthase in rat hepatic cells. Biochemical and immunochemical evidence

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Tissue fractionation studies. 17. Intracellular distribution of monoamine oxidase, aspartate aminotransferase, alanine aminotransferase, D-amino acid oxidase and catalase in rat-liver tissue

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Increased cholesterol synthesis in Chinese hamster ovary cells deficient in peroxisomes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Marked alteration of sterol metabolism and composition without compromising retinal development or function.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303355

Cholesterol biosynthesis in dermal fibroblasts from patients with metabolic disorders of peroxisomal origin

27 November 2018

1 reference

12 December 2020

Cholesterol synthesis in the vertebrate retina: effects of U18666A on rat retinal structure, photoreceptor membrane assembly, and sterol metabolism and composition

1 reference

12 December 2020

Reduced cellular cholesterol content in peroxisome-deficient fibroblasts is associated with impaired uptake of the patient's low density lipoprotein and with reduced cholesterol synthesis

1 reference

12 December 2020

Cholesterol biosynthesis in Zellweger syndrome: normal activity of mevalonate kinase, mevalonate-5'-pyrophosphate decarboxylase and IPP-isomerase in patients' fibroblasts but deficient mevalonate kinase activity in liver

1 reference

12 December 2020

Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines

1 reference

12 December 2020

Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia

1 reference

12 December 2020

10.1128/MCB.24.1.1-13.2004

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14673138%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14673138%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

2 references

31 January 2017