(Q28594242)

English

The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease

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scholarly article

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PubMed publication ID

31 January 2017

The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease (English)

1 reference

PubMed publication ID

31 January 2017

neuroendocrinology

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based on heuristic

inferred from title

Secretogranin V

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GOA release 2020-03-11

Cushing's disease

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based on heuristic

inferred from title

author name string

C. H. Westphal

1

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PubMed publication ID

31 January 2017

L. Muller

2

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PubMed publication ID

31 January 2017

A. Zhou

3

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PubMed publication ID

31 January 2017

X. Zhu

4

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PubMed publication ID

31 January 2017

S. Bonner-Weir

5

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PubMed publication ID

31 January 2017

M. Schambelan

6

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PubMed publication ID

31 January 2017

D. F. Steiner

7

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PubMed publication ID

31 January 2017

I. Lindberg

8

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PubMed publication ID

31 January 2017

P. Leder

9

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PubMed publication ID

31 January 2017

language of work or name

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publication date

5 March 1999

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PubMed publication ID

31 January 2017

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PubMed publication ID

31 January 2017

96

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PubMed publication ID

31 January 2017

5

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PubMed publication ID

31 January 2017

689–700

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PubMed publication ID

31 January 2017

Hormonal regulation of POMC gene expression

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

7B2 is a specific intracellular binding protein of the prohormone convertase PC2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure-function studies on the biosynthesis and bioactivity of the precursor convertase PC2 and the formation of the PC2/7B2 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Prohormone-converting enzymes: regulation and evaluation of function using antisense RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Pituitary hyperplasia induced by ectopic expression of nerve growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural organization of the gene encoding the neuroendocrine chaperone 7B2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Transmembrane signals mediating adrenocorticotropin release from mouse anterior pituitary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Histological evaluation of the dopaminergic regulation of proopiomelanocortin gene expression in the intermediate lobe of the rat pituitary, involving in situ hybridization and [3H]thymidine uptake measurement

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Differentiation in paediatric peripheral primitive neuroectodermal tumours of bone. A critical contribution to its assessment.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient integration of artificial transposons into plasmid targets in vitro: a useful tool for DNA mapping, sequencing and genetic analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide. Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Tissue distribution and molecular forms of a novel pituitary protein in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Processing site blockade results in more efficient conversion of proenkephalin to active opioid peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The Mechanism of the Suppressive Action of Bromocriptine on Adrenocorticotropin Secretion in Patients with Cushing′s Disease and Nelson′s Syndrome*

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Enzymatic characterization of immunopurified prohormone convertase 2: potent inhibition by a 7B2 peptide fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Pan-neuronal mRNA expression of the secretory polypeptide 7B2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting of transforming growth factor-alpha expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical and biochemical evaluation of Cushing's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of the facilitation of PC2 maturation by 7B2: involvement in ProPC2 transport and activation but not folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Secretory protein 7B2. A novel tumor marker of medullary carcinoma of the thyroid

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Bioactive and Immunoreactive Adrenocorticotropin in Normal Equine Pituitary and in Pituitary Tumors of Horses with Cushing's Disease*

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Dopaminergic regulation of secretory granule-associated proteins in rat intermediate pituitary

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteolytic processing of pro-ACTH/endorphin begins in the Golgi complex of pituitary corticotropes and AtT-20 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Eukaryotic protein processing: endoproteolysis of precursor proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuroendocrine protein 7B2 is essential for proteolytic conversion and activation of proprotein convertase 2 in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The proprotein convertases

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Mapping of the domain in the neuroendocrine protein 7B2 important for its helper function towards prohormone convertase PC2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of the neuroendocrine cell marker 7B2 in human ACTH secreting tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The mouse formin (Fmn) gene: genomic structure, novel exons, and genetic mapping

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Transposon-generated 'knock-out' and 'knock-in' gene-targeting constructs for use in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of a polyproline helix-like structure in the interaction of 7B2 with prohormone convertase 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural elements of PC2 required for interaction with its helper protein 7B2.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980579-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0092-8674(00)80579-6

0 references

PubMed publication ID

1 reference

PubMed publication ID

31 January 2017

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