(Q28741746)

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Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 June 2017

Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

author name string

Randi-Michelle Cowin

1

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Europe PubMed Central

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21 June 2017

Nghiem Bui

2

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Europe PubMed Central

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21 June 2017

Deanna Graham

3

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21 June 2017

Jennie R Green

4

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21 June 2017

Stephan Grueninger

5

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Europe PubMed Central

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21 June 2017

Lisa A Yuva-Paylor

6

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Europe PubMed Central

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21 June 2017

Arsalan U Syed

7

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Europe PubMed Central

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21 June 2017

Andreas Weiss

8

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21 June 2017

Richard Paylor

9

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21 June 2017

language of work or name

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publication date

7 December 2011

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Europe PubMed Central

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21 June 2017

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

6

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Europe PubMed Central

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21 June 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

e28409

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

copyright license

Creative Commons Attribution 4.0 International

7 December 2011

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April 2022 Public Data File from Crossref

copyright status

0 references

Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

17 March 2017

Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

17 March 2017

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

17 March 2017

Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

17 March 2017

A new mathematical model for relative quantification in real-time RT-PCR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

17 March 2017

Neurological abnormalities in a knock-in mouse model of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

17 March 2017

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

17 March 2017

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

17 March 2017

A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

17 March 2017

Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

17 March 2017

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

17 March 2017

Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

17 March 2017

Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

7 April 2017

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

7 April 2017

Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

CAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

MSH2-dependent germinal CTG repeat expansions are produced continuously in spermatogonia from DM1 transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Speed congenics: a classic technique in the fast lane (relatively speaking).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Trinucleotide repeat length instability and age of onset in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Correlation between the onset age of Huntington's disease and length of the trinucleotide repeat in IT-15.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Characterization of benzodiazepine-sensitive behaviors in the A/J and C57BL/6J inbred strains of mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Injections of atropine into the caudate nucleus impair the acquisition and the maintenance of passive avoidance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Thigmotaxis as a test for anxiolytic activity in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

3 June 2018

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Time-dependent deficits of rat's memory consolidation induced by tetrodotoxin injections into the caudate-putamen, nucleus accumbens, and globus pallidus.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Trinucleotide expansion in haploid germ cells by gap repair

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Somatic deletion events occur during early embryonic development and modify the extent of CAG expansion in subsequent generations

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Rigidity in social and emotional memory in the R6/2 mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

"Brain training" improves cognitive performance and survival in a transgenic mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Dopamine-dependent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Behaviour changes in a transgenic model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028409

21 January 2018

Longitudinal analysis of the behavioural phenotype in R6/1 (C57BL/6J) Huntington's disease transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

27 November 2018

Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL/6J) Huntington's disease transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

27 November 2018

Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington's disease knock-in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

27 November 2018

Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

27 November 2018

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3233565

27 November 2018

Identifiers

10.1371/JOURNAL.PONE.0028409

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

2011PLoSO...628409C

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PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

ResearchGate publication ID

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