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A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors

scientific article (publication date: 15 December 2009)

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A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors (English)

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Ajay Yekkirala

2

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author name string

Shijun Zhang

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1

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Ye Tang

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3

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Philip S Portoghese

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4

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English

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publication date

15 December 2009

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published in

Bioorganic & Medicinal Chemistry Letters

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volume

19

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issue

24

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page(s)

6978-80

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cites work

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Heterodimerization of mu and delta opioid receptors: A role in opiate synergy

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G-protein-coupled receptor heterodimerization modulates receptor function

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A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes

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A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers

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Identity of the putative δ1-opioid receptor as a δ–κ heteromer in the mouse spinal cord

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Oligomerization of opioid receptors: generation of novel signaling units

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Opioid agonist and antagonist bivalent ligands as receptor probes

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Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors

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Stereostructure-activity relationship of opioid agonist and antagonist bivalent ligands. Evidence for bridging between vicinal opioid receptors

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[3H]U-69593 a highly selective ligand for the opioid kappa receptor

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Identifiers

DOI

10.1016/J.BMCL.2009.10.045

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PMC publication ID

5060004

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PubMed publication ID

19892550

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(Q28822182)

A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors

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