(Q28829881)

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Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

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scholarly article

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Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells (English)

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Matthew R. Hepworth

object named as

Matthew R Hepworth

2

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object named as

Marc Veldhoen

9

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David R Withers

object named as

David R Withers

1

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author name string

Xinxin Wang

3

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Emma C Mackley

4

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Emily E Halford

5

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Emma E Dutton

6

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Clare L Marriott

7

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Verena Brucklacher-Waldert

8

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Judith Kelsen

10

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Robert N Baldassano

11

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Gregory F Sonnenberg

12

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language of work or name

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publication date

March 2016

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Nature Medicine

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22

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3

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319-23

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The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

1 reference

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16 March 2017

IL-17 and Th17 Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

16 March 2017

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

16 March 2017

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

16 March 2017

Transforming growth factor-beta induces development of the T(H)17 lineage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

16 March 2017

The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patches

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

16 March 2017

https://api.crossref.org/works/10.1038%2FNM.4046

23 May 2017

Innate lymphoid cells--a proposal for uniform nomenclature

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

7 April 2017

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

7 April 2017

Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Innate lymphoid cells in the initiation, regulation and resolution of inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Not all monoclonals are created equal - lessons from failed drug trials in Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

IL-17 regulates systemic fungal immunity by controlling the functional competence of NK cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Small molecule inhibitors of RORγt: targeting Th17 cells and other applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Generation of CD4CreER(T²) transgenic mice to study development of peripheral CD4-T-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

A protective function for interleukin 17A in T cell-mediated intestinal inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

Claudins regulate the intestinal barrier in response to immune mediators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4948756

3 June 2018

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

1 reference

https://api.crossref.org/works/10.1038%2FNM.4046

21 January 2018

Secukinumab failure in Crohn's disease: the yeast connection?

1 reference

https://api.crossref.org/works/10.1038%2FNM.4046

21 January 2018

Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection

1 reference

https://api.crossref.org/works/10.1038%2FNM.4046

21 January 2018

Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.

1 reference

https://api.crossref.org/works/10.1038%2FNM.4046

21 January 2018

A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells

1 reference

https://api.crossref.org/works/10.1038%2FNM.4046

21 January 2018

Lineage Relationship Analysis of RORγt+Innate Lymphoid Cells

1 reference

https://api.crossref.org/works/10.1038%2FNM.4046

21 January 2018

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FNM.4046

21 January 2018

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FNM.4046

21 January 2018

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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