(Q29147438)

4 April 2017

title

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27) (English)

1 reference

Enhancer of zeste 2 polycomb repressive complex 2 subunit

4 April 2017

0 references

1 reference

histone methyltransferase activity (H3-K27 specific)

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Michael T. McCabe

1

1 reference

4 April 2017

Alan P. Graves

2

1 reference

4 April 2017

Gopinath Ganji

3

1 reference

4 April 2017

Elsie Diaz

4

1 reference

4 April 2017

Wendy S. Halsey

5

1 reference

4 April 2017

Yong Jiang

6

1 reference

4 April 2017

Kimberly N. Smitheman

7

1 reference

4 April 2017

Heidi M. Ott

8

1 reference

4 April 2017

Melissa B. Pappalardi

9

1 reference

4 April 2017

Kimberly E. Allen

10

1 reference

4 April 2017

Stephanie B. Chen

11

1 reference

4 April 2017

Anthony Della Pietra

12

1 reference

4 April 2017

Edward Dul

13

1 reference

4 April 2017

Ashley M. Hughes

14

1 reference

4 April 2017

Seth A. Gilbert

15

1 reference

4 April 2017

Sara H. Thrall

16

1 reference

4 April 2017

Peter J. Tummino

17

1 reference

4 April 2017

Ryan G. Kruger

18

1 reference

4 April 2017

Martin Brandt

19

1 reference

4 April 2017

Benjamin Schwartz

20

1 reference

4 April 2017

Caretha L. Creasy

21

1 reference

4 April 2017

language of work or name

English

0 references

publication date

21 February 2012

1 reference

Proceedings of the National Academy of Sciences of the United States of America

4 April 2017

published in

1 reference

4 April 2017

volume

109

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4 April 2017

issue

8

1 reference

4 April 2017

page(s)

2989–2994

1 reference

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

4 April 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

SET7/9 Catalytic Mutants Reveal the Role of Active Site Water Molecules in Lysine Multiple Methylation

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Structural Biology of Human H3K9 Methyltransferases

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Structural origins for the product specificity of SET domain protein methyltransferases

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

High-resolution profiling of histone methylations in the human genome

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Structural basis for the product specificity of histone lysine methyltransferases

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Structure and catalytic mechanism of the human histone methyltransferase SET7/9

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

The mutational landscape of head and neck squamous cell carcinoma

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

EZH2 Y641 mutations in follicular lymphoma.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Roles of the EZH2 histone methyltransferase in cancer epigenetics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Somatic mutations and intraclonal variations in the rearranged Vkappa genes of B-non-Hodgkin's lymphoma cell lines.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3287005

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1116418109

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1116418109

Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1116418109

Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22323599

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Abnormal histone acetylation and methylation levels in esophageal squamous cell carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22323599

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Global histone H3 lysine 27 (H3K27) methylation levels and their prognostic relevance in renal cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22323599

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1116418109

1 reference

ADS bibcode

2012PNAS..109.2989M

0 references

1 reference

1 reference

1 reference