(Q29347071)

11 April 2017

Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium (English)

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11 April 2017

protein ubiquitination

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Rebecca K Harston

1

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11 April 2017

John C McKillop

2

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11 April 2017

Phillip C Moschella

3

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11 April 2017

An Van Laer

4

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11 April 2017

Lakeya S Quinones

5

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11 April 2017

Catalin F Baicu

6

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11 April 2017

Sundaravadivel Balasubramanian

7

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11 April 2017

Michael R Zile

8

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11 April 2017

Dhandapani Kuppuswamy

9

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11 April 2017

25 February 2011

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American Journal of Physiology Heart and Circulatory Physiology

11 April 2017

1 reference

11 April 2017

300

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11 April 2017

5

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11 April 2017

H1696-706

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describes a project that uses

11 April 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3094075/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

TOR signaling in growth and metabolism

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

Beta3 integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophy

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

Response and adaptation of skeletal muscle to denervation stress: the role of apoptosis in muscle loss.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

mTOR in growth and protection of hypertrophying myocardium

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

In vivo administration of calpeptin attenuates calpain activation and cardiomyocyte loss in pressure-overloaded feline myocardium.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

3 June 2018

The two TORCs and Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

Akt/protein kinase B promotes organ growth in transgenic mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

Integrin activation and focal complex formation in cardiac hypertrophy.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

Contractile function of isolated feline cardiocytes in response to viscous loading

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3094075

Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases.

3 June 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00545.2010

The mTOR/p70S6K signal transduction pathway plays a role in cardiac hypertrophy and influences expression of myosin heavy chain genes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00545.2010

Mechanisms for the abnormal energetics of pressure-induced hypertrophy of cat myocardium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00545.2010

Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00545.2010

Caspase activation and apoptosis in response to proteasome inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00545.2010

Myocytes die by multiple mechanisms in failing human hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00545.2010

Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00545.2010

Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00545.2010

Rapamycin attenuates load-induced cardiac hypertrophy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00545.2010

Repression of protein translation and mTOR signaling by proteasome inhibitor in colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00545.2010

Translational mechanisms accelerate the rate of protein synthesis during canine pressure-overload hypertrophy

21 January 2018

1 reference

12 December 2020

Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO

1 reference

12 December 2020

A method for producing reversible long-term pressure overload of the cat right ventricle

1 reference

12 December 2020

Association of tyrosine-phosphorylated c-Src with the cytoskeleton of hypertrophying myocardium

1 reference

12 December 2020

Role of microtubules in the contractile dysfunction of hypertrophied myocardium

1 reference

12 December 2020

Depression of proteasome activities during the progression of cardiac dysfunction in pressure-overloaded heart of mice

1 reference

12 December 2020

Akt1 is required for physiological cardiac growth

1 reference

12 December 2020

Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis

1 reference

12 December 2020

Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy

1 reference

12 December 2020

10.1152/AJPHEART.00545.2010

Identifiers

DOI

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11 April 2017

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