(Q29814411)

English

Patched Dmel_CG2411

Protein found in Drosophila melanogaster

patched
CG2411-PA
CG2411 gene product from transcript CG2411-RA
ptc-PA
rubberneck
confused
ptc
tufted
patch
compaction defects 4

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Transmembrane receptor, patched

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18502

Eukaryotic Sterol Transporter

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Sterol-sensing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transmembrane signaling receptor activity

determination method

1 reference

10 September 2018

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

protein binding

determination method

3 references

9 May 2019

Understanding human cancer using Drosophila: Tid47, a cytosolic product of the DnaJ-like tumor suppressor gene l2Tid, is a novel molecular partner of patched related to skin cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

9 May 2019

Genetic and biochemical definition of the Hedgehog receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

9 May 2019

A large complex containing Patched and Smoothened initiates Hedgehog signaling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

hedgehog receptor activity

determination method

4 references

21 June 2018

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

21 June 2018

Regulation of Hedgehog signaling: a complex story

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

21 June 2018

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

lipoprotein particle receptor activity

determination method

1 reference

9 May 2019

Patched, the receptor of Hedgehog, is a lipoprotein receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

smoothened binding

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

hedgehog receptor activity

determination method

5 references

10 September 2018

Regulation of Hedgehog signaling: a complex story

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

10 September 2018

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

10 September 2018

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

hedgehog family protein binding

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

hedgehog receptor activity

determination method

3 references

9 May 2019

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

phosphatidylinositol-4-phosphate binding

determination method

1 reference

9 May 2019

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

determination method

1 reference

7 November 2018

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

determination method

1 reference

9 May 2019

Cilia-mediated hedgehog signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

integral component of membrane

determination method

3 references

1 January 2018

Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

endocytic vesicle

determination method

1 reference

9 May 2019

Patched, the receptor of Hedgehog, is a lipoprotein receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

determination method

1 reference

9 May 2019

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

perinuclear region of cytoplasm

determination method

1 reference

7 November 2018

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

plasma membrane

determination method

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

9 May 2019

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

basal plasma membrane

determination method

1 reference

9 May 2019

Cytoneme-mediated cell-cell contacts for Hedgehog reception.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

biological process

Bolwig's organ morphogenesis

determination method

1 reference

9 May 2019

Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

determination method

1 reference

7 November 2018

The sterol-sensing domain: multiple families, a unique role?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

receptor-mediated endocytosis

determination method

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

smoothened signaling pathway

determination method

6 references

21 June 2018

Cholesterol metabolism and embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

21 June 2018

Regulation of Hedgehog signaling: a complex story

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

21 June 2018

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

21 June 2018

A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

21 June 2018

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

21 June 2018

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

regulation of mitotic cell cycle

determination method

1 reference

9 May 2019

Hedgehog acts as a somatic stem cell factor in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

segment polarity determination

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

determination method

1 reference

9 May 2019

Patched regulation of axon guidance is by specifying neural identity in the Drosophila nerve cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

peripheral nervous system development

determination method

1 reference

1 January 2018

Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

eye-antennal disc morphogenesis

determination method

1 reference

9 May 2019

A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

imaginal disc-derived wing morphogenesis

determination method

1 reference

9 May 2019

Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

gonad development

determination method

1 reference

9 May 2019

A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

embryonic pattern specification

determination method

1 reference

1 January 2018

Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

anterior/posterior pattern specification

determination method

1 reference

10 September 2018

The sterol-sensing domain: multiple families, a unique role?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

dephosphorylation

determination method

1 reference

7 November 2018

The sterol-sensing domain: multiple families, a unique role?

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

ovarian follicle cell development

determination method

1 reference

1 January 2018

Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

determination of genital disc primordium

determination method

1 reference

9 May 2019

Allocation and specification of the genital disc precursor cells in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

germ-line stem cell division

determination method

1 reference

7 November 2018

The stem-cell niche theory: lessons from flies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

regulation of apoptotic process

determination method

1 reference

9 May 2019

Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

anterior/posterior lineage restriction, imaginal disc

determination method

1 reference

9 May 2019

Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

wing disc anterior/posterior pattern formation

determination method

1 reference

9 May 2019

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

somatic stem cell division

determination method

1 reference

9 May 2019

The stem-cell niche theory: lessons from flies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

determination method

1 reference

7 November 2018

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

lipid homeostasis

determination method

1 reference

9 May 2019

Patched, the receptor of Hedgehog, is a lipoprotein receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

regulation of epithelial cell migration, open tracheal system

determination method

1 reference

9 May 2019

Hedgehog is a positive regulator of FGF signalling during embryonic tracheal cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

smoothened signaling pathway

determination method

7 references

10 September 2018

Regulation of Hedgehog signaling: a complex story

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

10 September 2018

Cholesterol metabolism and embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

10 September 2018

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

10 September 2018

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

10 September 2018

A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

10 September 2018

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18502&geneProductId=UniProtKB:P18502

determination method

smoothened signaling pathway

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

ovarian follicle cell development

determination method

1 reference

9 May 2019

Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

negative regulation of smoothened signaling pathway

determination method

4 references

9 May 2019

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

9 May 2019

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

9 May 2019

The role of segment polarity genes during early oogenesis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

9 May 2019

Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

vesicle-mediated transport

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18502

determination method

Sterol-sensing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18502

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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