(Q29816233)

English

WRN exonuclease Dmel_CG7670

Protein found in Drosophila melanogaster

CG7670-PA
CG7670 gene product from transcript CG7670-RC
WRNexo-PA
CG7670-PB
WRNexo-PC
WRNexo
CG7670-PC
WRN exonuclease
WRNexo-PB

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Statements

1 reference

25 May 2022

Ribonuclease H superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9VE86

Ribonuclease H-like superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9VE86

3'-5' exonuclease domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

determination method

IEA

single-stranded DNA 3'-5' exodeoxyribonuclease activity

1 reference

8 April 2019

The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

determination method

IDA

double-stranded DNA 3'-5' exodeoxyribonuclease activity

2 references

8 April 2019

A fluorescence-based exonuclease assay to characterize DmWRNexo, orthologue of human progeroid WRN exonuclease, and its application to other nucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

8 April 2019

The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

determination method

IDA

3'-5' exonuclease activity

4 references

16 July 2018

Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VE86&geneProductId=UniProtKB:Q9VE86

16 July 2018

DNA repair in Drosophila: insights from the Drosophila genome sequence.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VE86&geneProductId=UniProtKB:Q9VE86

16 July 2018

DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VE86&geneProductId=UniProtKB:Q9VE86

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VE86&geneProductId=UniProtKB:Q9VE86

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

determination method

IEA

3'-5' exonuclease activity

5 references

8 April 2019

DNA repair in Drosophila: insights from the Drosophila genome sequence.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

8 April 2019

Modeling Werner Syndrome in Drosophila melanogaster: hyper-recombination in flies lacking WRN-like exonuclease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

8 April 2019

DmWRNexo is a 3'-5' exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

determination method

IBA

biological process

DNA catabolic process, exonucleolytic

determination method

IC

IDA

nucleobase-containing compound metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

determination method

IEA

negative regulation of mitotic recombination

1 reference

8 April 2019

Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

determination method

IMP

replication fork protection

1 reference

8 April 2019

The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VE86

determination method

IGI

has part(s)

3'-5' exonuclease domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9VE86

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

(Q29816233)

WRN exonuclease Dmel_CG7670

Statements

Identifiers

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