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Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium
scientific article published on 29 July 2015
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4518712
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20 February 2020
title
Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium
(English)
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4518712
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20 February 2020
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Lydia W T Cheung
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1
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20 February 2020
David H Hawke
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20 February 2020
Stefan T Arold
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20 February 2020
Gordon B. Mills
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Gordon B Mills
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20 February 2020
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Katarzyna W Walkiewicz
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2
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20 February 2020
Tabot M D Besong
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3
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20 February 2020
Huifang Guo
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29 July 2015
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20 February 2020
published in
eLife
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20 February 2020
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4
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20 February 2020
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e06866
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20 February 2020
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The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway
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3 June 2018
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
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3 June 2018
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase
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3 June 2018
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3 June 2018
Binding of a diphosphotyrosine-containing peptide that mimics activated platelet-derived growth factor receptor beta induces oligomerization of phosphatidylinositol 3-kinase
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3 June 2018
Calcium-dependent membrane penetration is a hallmark of the C2 domain of cytosolic phospholipase A2 whereas the C2A domain of synaptotagmin binds membranes electrostatically.
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3 June 2018
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.
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3 June 2018
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
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Crossref
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21 January 2018
Identifiers
DOI
10.7554/ELIFE.06866
1 reference
stated in
Europe PubMed Central
PMC publication ID
4518712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26222500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
PMC publication ID
4518712
1 reference
stated in
Europe PubMed Central
PMC publication ID
4518712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26222500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
PubMed publication ID
26222500
1 reference
stated in
Europe PubMed Central
PMC publication ID
4518712
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26222500%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 February 2020
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