(Q30009548)

21 May 2017

title

Locking the active conformation of c-Src kinase through the phosphorylation of the activation loop (English)

1 reference

21 May 2017

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Yilin Meng

1

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21 May 2017

Benoît Roux

series ordinal

2

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21 May 2017

language of work or name

English

0 references

publication date

6 October 2013

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Journal of Molecular Biology

21 May 2017

published in

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21 May 2017

volume

426

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21 May 2017

issue

2

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21 May 2017

page(s)

423-435

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

21 May 2017

cites work

1 reference

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22 May 2017

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Mutations in the catalytic loop HRD motif alter the activity and function of Drosophila Src64

22 May 2017

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22 May 2017

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22 May 2017

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Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

22 May 2017

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22 May 2017

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Src kinase regulation by phosphorylation and dephosphorylation

22 May 2017

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Regulation of protein kinases; controlling activity through activation segment conformation

22 May 2017

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Src family kinases in tumor progression and metastasis

22 May 2017

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Protein kinases--the major drug targets of the twenty-first century?

22 May 2017

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22 May 2017

The hunting of the Src

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Protein tyrosine kinase structure and function

22 May 2017

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Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

22 May 2017

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

22 May 2017

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Cellular functions regulated by Src family kinases

22 May 2017

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Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

22 May 2017

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Protein kinases: evolution of dynamic regulatory proteins

22 May 2017

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Self-Learning Adaptive Umbrella Sampling Method for the Determination of Free Energy Landscapes in Multiple Dimensions

22 May 2017

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Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases

3 June 2018

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αC helix as a switch in the conformational transition of Src/CDK-like kinase domains

3 June 2018

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MSMBuilder2: Modeling Conformational Dynamics at the Picosecond to Millisecond Scale

3 June 2018

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Defining the conserved internal architecture of a protein kinase.

3 June 2018

1 reference

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Progress and challenges in the automated construction of Markov state models for full protein systems

3 June 2018

1 reference

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Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectories

3 June 2018

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A helix scaffold for the assembly of active protein kinases

3 June 2018

1 reference

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Building Markov state models along pathways to determine free energies and rates of transitions

3 June 2018

1 reference

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An electrostatic network and long-range regulation of Src kinases

3 June 2018

1 reference

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Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases

3 June 2018

1 reference

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Structure and dynamic regulation of Src-family kinases

3 June 2018

1 reference

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Src kinase conformational activation: thermodynamics, pathways, and mechanisms

3 June 2018

1 reference

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Finding transition pathways using the string method with swarms of trajectories

3 June 2018

1 reference

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On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases

3 June 2018

1 reference

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Protein tyrosine kinase-substrate interactions

3 June 2018

1 reference

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Src kinase activation: A switched electrostatic network

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3947352

The N-terminal end of the catalytic domain of SRC kinase Hck is a conformational switch implicated in long-range allosteric regulation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3947352

The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3947352

Structure and regulation of Src family kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3947352

Protein kinase inhibitors: insights into drug design from structure.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3947352

Kinetic and catalytic mechanisms of protein kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3947352

Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3947352

Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3947352

Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3947352

Atomistic view of the conformational activation of Src kinase using the string method with swarms-of-trajectories

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3947352

String method in collective variables: minimum free energy paths and isocommittor surfaces.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3947352

2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor

26 November 2018

1 reference