(Q30165193)

9 June 2017

title

Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain (English)

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9 June 2017

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Steven J Schreiner

1

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9 June 2017

Anthony P Schiavone

series ordinal

2

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9 June 2017

Thomas E Smithgall

series ordinal

3

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9 June 2017

language of work or name

English

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publication date

19 September 2002

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Journal of Biological Chemistry

9 June 2017

published in

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9 June 2017

volume

277

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9 June 2017

issue

47

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9 June 2017

page(s)

45680-45687

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Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

9 June 2017

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SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts.

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The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.

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Stat3 activation by Src induces specific gene regulation and is required for cell transformation

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Activation and association of Stat3 with Src in v-Src-transformed cell lines

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Tyrosine phosphorylation enhances the SH2 domain-binding activity of Bcr and inhibits Bcr interaction with 14-3-3 proteins

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SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.

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BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias

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21 January 2018

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Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity

21 January 2018

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Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation

21 January 2018

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The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein

21 January 2018

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21 January 2018

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Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

21 January 2018

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Control of myeloid differentiation and survival by Stats

21 January 2018

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Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs

21 January 2018

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Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity

21 January 2018

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The Src-family kinase Lck can induce STAT3 phosphorylation and DNA binding activity

21 January 2018

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Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

21 January 2018

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Three-dimensional structure of the Stat3beta homodimer bound to DNA

21 January 2018

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STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor

21 January 2018

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The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling

21 January 2018

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Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src

21 January 2018

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Regulation of c-SRC activity and function by the adapter protein CAS

21 January 2018

1 reference

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Processive phosphorylation of p130Cas by Src depends on SH3-polyproline interactions

21 January 2018

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Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M204255200

1 reference

9 June 2017

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