(Q30168478)

English

A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

R Egelund

1

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

T E Petersen

2

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

P A Andreasen

3

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

language of work or name

0 references

publication date

1 February 2001

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

268

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

673-685

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

What do dysfunctional serpins tell us about molecular mobility and disease?

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Divining the serpin inhibition mechanism: a suicide substrate 'springe'?

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Major proteinase movement upon stable serpin-proteinase complex formation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Mapping the serpin-proteinase complex using single cysteine variants of alpha1-proteinase inhibitor Pittsburgh

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

An ester bond linking a fragment of a serine proteinase to its serpin inhibitor.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Routes of Thrombin Action in the Production of Proteolytically Modified, Secondary Forms of Antithrombin-Thrombin Complex

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Plasminogen activator inhibitors: hormonally regulated serpins

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

The urokinase-type plasminogen activator system in cancer metastasis: a review

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

The plasminogen activation system in tumor growth, invasion, and metastasis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Interconversions between active, inert and substrate forms of denatured/refolded type-1 plasminogen activator inhibitor

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Tissue-type plasminogen activator: variants and crystal/solution structures demarcate structural determinants of function

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Purification of zymogen to plasminogen activator from human glioblastoma cells by affinity chromatography with monoclonal antibody.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

The crystal structure of the catalytic domain of human urokinase-type plasminogen activator

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Modeling studies of the change in conformation required for cleavage of limited proteolytic sites

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Probing the partly folded states of proteins by limited proteolysis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

The three-dimensional structure of Asp189Ser trypsin provides evidence for an inherent structural plasticity of the protease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Crystal structure of the proenzyme domain of plasminogen

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Human plasminogen catalytic domain undergoes an unusual conformational change upon activation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Structural basis of the activation and action of trypsin

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Serpin-protease complexes are trapped as stable acyl-enzyme intermediates

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Structural insights into serpin-protease complexes reveal the inhibitory mechanism of serpins

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

The structure of a serpin-protease complex revealed by intramolecular distance measurements using donor-donor energy migration and mapping of interaction sites

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Conformational stability of the covalent complex between elastase and alpha 1-proteinase inhibitor

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Trypsin complexed with alpha 1-proteinase inhibitor has an increased structural flexibility

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Distortion of the active site of chymotrypsin complexed with a serpin

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Properties of the His57-Asp102 dyad of rat trypsin D189S in the zymogen, activated enzyme, and alpha1-proteinase inhibitor complexed forms

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Immunohistochemical localization of urokinase-type plasminogen activator, type-1 plasminogen-activator inhibitor, urokinase receptor and alpha(2)-macroglobulin receptor in human breast carcinomas

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Type-1 plasminogen-activator inhibitor -- conformational differences between latent, active, reactive-centre-cleaved and plasminogen-activator-complexed forms, as probed by proteolytic susceptibility

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Type-1 inhibitor of plasminogen activators. Distinction between latent, activated and reactive centre-cleaved forms with thermal stability and monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

The complete amino acid sequence of low molecular mass urokinase from human urine

1 reference

https://api.crossref.org/works/10.1046%2FJ.1432-1327.2001.01921.X

21 January 2018

Identifiers

10.1046/J.1432-1327.2001.01921.X

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

ResearchGate publication ID

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