(Q30252581)

13 June 2017

In silico assessment of biomedical products: The conundrum of rare but not so rare events in two case studies (English)

1 reference

13 June 2017

1 reference

2

Claudio Cobelli

1 reference

13 June 2017

5

Boris Kovatchev

1 reference

13 June 2017

Marco Viceconti

1

1 reference

13 June 2017

Tarek Haddad

series ordinal

3

1 reference

13 June 2017

Adam Himes

series ordinal

4

1 reference

13 June 2017

Mark Palmer

series ordinal

6

1 reference

13 June 2017

1 May 2017

1 reference

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

13 June 2017

1 reference

13 June 2017

231

1 reference

13 June 2017

5

1 reference

13 June 2017

455-466

1 reference

Innovation in the pharmaceutical industry: New estimates of R&D costs

13 June 2017

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

In silico SNP analysis and bioinformatics tools: a review of the state of the art to aid drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Network-based discovery through mechanistic systems biology. Implications for applications--SMEs and drug discovery: where the action is.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Insights in the mechanism of action and inhibition of N-acylethanolamine acid amidase by means of computational methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Application of population pharmacokinetics for preclinical safety and efficacy studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

The CellML Model Repository

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Modelling biological modularity with CellML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

FieldML: concepts and implementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

FieldML, a proposed open standard for the Physiome project for mathematical model representation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

The analysis of cardiac function: a continuum approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

The Cardiome Project. An integrated view of cardiac metabolism and regional mechanical function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Computed fractional flow reserve (FFTCT) derived from coronary CT angiography

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

euHeart: personalized and integrated cardiac care using patient-specific cardiovascular modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Personalization of atrial anatomy and electrophysiology as a basis for clinical modeling of radio-frequency ablation of atrial fibrillation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Patient-specific finite element models to support clinical decisions: A lesson learnt from a case study of percutaneous pulmonary valve implantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

MRI model-based non-invasive differential diagnosis in pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

A novel strategy to translate the biomechanical rupture risk of abdominal aortic aneurysms to their equivalent diameter risk: method and retrospective validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Multiscale investigation of the functional properties of the human femur.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Multiscale modelling of the skeleton for the prediction of the risk of fracture

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Patient-specific finite element estimated femur strength as a predictor of the risk of hip fracture: the effect of methodological determinants

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

A cerebral palsy assessment tool using anatomically based geometries and free-form deformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Subject-specific modelling of lower limb muscles in children with cerebral palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Calculating gait kinematics using MR-based kinematic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Three-dimensional computed tomography for determination of femoral anteversion in a cerebral palsy model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Computational tools for calculating alternative muscle force patterns during motion: a comparison of possible solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Effect of sub-optimal neuromotor control on the hip joint load during level walking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Stochastic modelling of muscle recruitment during activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

A finite element model predicts the mechanotransduction response of tendon cells to cyclic tensile loading.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

An insight on multiscale tendon modeling in muscle-tendon integrated behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

A conceptual framework for computational models of Achilles tendon homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Incorporating plasticity of the interfibrillar matrix in shear lag models is necessary to replicate the multiscale mechanics of tendon fascicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

'Universal' microstructural patterns in cortical and trabecular, extracellular and extravascular bone materials: micromechanics-based prediction of anisotropic elasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Human cortical bone: the SiNuPrOs model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Nonlinear hierarchical multiscale modeling of cortical bone considering its nanoscale microstructure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Experimentally-based multiscale model of the elastic moduli of bovine trabecular bone and its constituents

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Patient-specific fibre-based models of muscle wrapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Modelling the passive and nerve activated response of the rectus femoris muscle to a flexion loading: a finite element framework.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Multiscale modeling of skeletal muscle properties and experimental validations in isometric conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

A multiscale chemo-electro-mechanical skeletal muscle model to analyze muscle contraction and force generation for different muscle fiber arrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

A multiscale framework based on the physiome markup languages for exploring the initiation of osteoarthritis at the bone-cartilage interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Effects of nonlinear muscle elasticity on pelvic floor mechanics during vaginal childbirth

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Predicting the Response of Breast Cancer to Neoadjuvant Therapy Using a Mechanically Coupled Reaction-Diffusion Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Global and societal implications of the diabetes epidemic

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Global estimates of the prevalence of diabetes for 2010 and 2030

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Economic costs of diabetes in the U.S. in 2012

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

A physiological model of glucose-insulin interaction in type 1 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

DHEA in elderly women and DHEA or testosterone in elderly men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Effects of age and sex on postprandial glucose metabolism: differences in glucose turnover, insulin secretion, insulin action, and hepatic insulin extraction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

GIM, simulation software of meal glucose-insulin model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Meal simulation model of the glucose-insulin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Evaluation of the effect of gain on the meal response of an automated closed-loop insulin delivery system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Feasibility of automating insulin delivery for the treatment of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

In silico preclinical trials: a proof of concept in closed-loop control of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

The UVA/PADOVA Type 1 Diabetes Simulator: New Features

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Multinational study of subcutaneous model-predictive closed-loop control in type 1 diabetes mellitus: summary of the results

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

2 month evening and night closed-loop glucose control in patients with type 1 diabetes under free-living conditions: a randomised crossover trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Multinational Home Use of Closed-Loop Control Is Safe and Effective

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Day-and-Night Closed-Loop Glucose Control in Patients With Type 1 Diabetes Under Free-Living Conditions: Results of a Single-Arm 1-Month Experience Compared With a Previously Reported Feasibility Study of Evening and Night at Home

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

The Artificial Pancreas in 2016: A Digital Treatment Ecosystem for Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

The university of Virginia/Padova type 1 diabetes simulator matches the glucose traces of a clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Diurnal pattern of insulin action in type 1 diabetes: implications for a closed-loop system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Circadian variability of insulin sensitivity: physiological input for in silico artificial pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

One-Day Bayesian Cloning of Type 1 Diabetes Subjects: Toward a Single-Day UVA/Padova Type 1 Diabetes Simulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Model individualization for artificial pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Regulation Catches Up to Reality

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Coverage of prandial insulin requirements by means of an ultra-rapid-acting inhaled insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Inhaled Technosphere Insulin Compared With Injected Prandial Insulin in Type 1 Diabetes: A Randomized 24-Week Trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Improving Efficacy of Inhaled Technosphere Insulin (Afrezza) by Postmeal Dosing: In-silico Clinical Trial with the University of Virginia/Padova Type 1 Diabetes Simulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Stresses from flexure in composite helical implantable leads

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Incorporation of stochastic engineering models as prior information in Bayesian medical device trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

Are spontaneous fractures possible? An example of clinical application for personalised, multiscale neuro-musculo-skeletal modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0954411917702931

21 January 2018

Identifiers

DOI

10.1177/0954411917702931

1 reference

13 June 2017

1 reference