(Q30277782)

14 June 2017

title

Proton detection and breathing regulation by the retrotrapezoid nucleus (English)

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14 June 2017

main subject

retrotrapezoid nucleus

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8

Roy Kanbar

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14 June 2017

2

Douglas A Bayliss

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14 June 2017

1

Patrice G Guyenet

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14 June 2017

3

Ruth L Stornetta

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ORCID Public Data File 2021

14 June 2017

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author name string

Marie-Gabrielle Ludwig

4

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14 June 2017

Natasha N Kumar

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14 June 2017

Yingtang Shi

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14 June 2017

Peter G R Burke

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14 June 2017

Tyler M Basting

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14 June 2017

Benjamin B Holloway

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14 June 2017

Ian C Wenker

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14 June 2017

language of work or name

English

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publication date

8 January 2016

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14 June 2017

published in

Journal of Physiology

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14 June 2017

volume

594

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14 June 2017

issue

6

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14 June 2017

page(s)

1529-1551

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Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats

14 June 2017

cites work

1 reference

Photostimulation of retrotrapezoid nucleus phox2b-expressing neurons in vivo produces long-lasting activation of breathing in rats

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Functional Oxygen Sensitivity of Astrocytes.

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Acute exercise-induced activation of Phox2b-expressing neurons of the retrotrapezoid nucleus in rats may involve the hypothalamus

21 January 2018

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Hypoxia silences retrotrapezoid nucleus respiratory chemoreceptors via alkalosis

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Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage.

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Pre-Bötzinger complex receives glutamatergic innervation from galaninergic and other retrotrapezoid nucleus neurons

21 January 2018

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Effect of hypoxia on the activity of respiratory and non-respiratory modulated retrotrapezoid neurons of the cat.

21 January 2018

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Functional and developmental identification of a molecular subtype of brain serotonergic neuron specialized to regulate breathing dynamics

21 January 2018

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Optogenetic stimulation of adrenergic C1 neurons causes sleep state-dependent cardiorespiratory stimulation and arousal with sighs in rats

21 January 2018

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State-dependent control of breathing by the retrotrapezoid nucleus

21 January 2018

1 reference

Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs

21 January 2018

1 reference

Oxygen regulation of breathing through an olfactory receptor activated by lactate

21 January 2018

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High-performance genetically targetable optical neural silencing by light-driven proton pumps

21 January 2018

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Regulation of the chemosensory control of breathing by Kölliker-Fuse neurons.

21 January 2018

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Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness.

21 January 2018

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Neuromodulation and the orchestration of the respiratory rhythm.

21 January 2018

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A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons.

21 January 2018

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Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons

21 January 2018

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Respiratory effects of carbon dioxide-induced changes of medullary extracellular fluid pH in cats

21 January 2018

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Heterogeneous patterns of pH regulation in glial cells in the dorsal and ventral medulla

21 January 2018

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Facing the challenge of mammalian neural microcircuits: taking a few breaths may help

21 January 2018

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The essential role of peripheral respiratory chemoreceptor inputs in maintaining breathing revealed when CO2 stimulation of central chemoreceptors is diminished.

21 January 2018

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Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal

21 January 2018

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Plasticity in the control of breathing following sensory denervation

21 January 2018

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Activation of the retrotrapezoid nucleus by posterior hypothalamic stimulation

21 January 2018

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Conditional depletion of methyl-CpG-binding protein 2 in astrocytes depresses the hypercapnic ventilatory response in mice.

21 January 2018

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Task2 potassium channels set central respiratory CO2 and O2 sensitivity.

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21 January 2018

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On the peripheral and central chemoreception and control of breathing: an emerging role of ATP.

21 January 2018

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21 January 2018

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Astrocytes control breathing through pH-dependent release of ATP

21 January 2018

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Release of ATP in the ventral medulla during hypoxia in rats: role in hypoxic ventilatory response.

21 January 2018

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The 2008 Carl Ludwig Lecture: retrotrapezoid nucleus, CO2 homeostasis, and breathing automaticity

21 January 2018

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Regulation of breathing and autonomic outflows by chemoreceptors

21 January 2018

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Regulation of ventral surface chemoreceptors by the central respiratory pattern generator.

21 January 2018

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KCNQ channels determine serotonergic modulation of ventral surface chemoreceptors and respiratory drive

21 January 2018

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Medullary serotonin neurons and their roles in central respiratory chemoreception.

21 January 2018

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The retrotrapezoid nucleus stimulates breathing by releasing glutamate in adult conscious mice

21 January 2018

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Effect of sleep stage on breathing in children with central hypoventilation

21 January 2018

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Role of parafacial nuclei in control of breathing in adult rats

21 January 2018

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CO2-dependent opening of connexin 26 and related β connexins

21 January 2018

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A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons

21 January 2018

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Distinct rhythm generators for inspiration and expiration in the juvenile rat

21 January 2018

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Differential sensitivity of brainstem versus cortical astrocytes to changes in pH reveals functional regional specialization of astroglia

21 January 2018

1 reference

The exercise pressor reflex in animals

21 January 2018

1 reference

Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal.

21 January 2018

1 reference

Astrocyte contributions to flow/pressure-evoked parenchymal arteriole vasoconstriction

21 January 2018

1 reference

Central pathways of pulmonary and lower airway vagal afferents

21 January 2018

1 reference

PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons

21 January 2018

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Acid sensitivity and ultrastructure of the retrotrapezoid nucleus in Phox2b-EGFP transgenic mice

21 January 2018

1 reference

Orexin A activates retrotrapezoid neurons in mice

21 January 2018

1 reference

Remote control of respiratory neural network by spinal locomotor generators

21 January 2018

1 reference

Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle.

21 January 2018

1 reference

CO2 dialysis in one chemoreceptor site, the RTN: stimulus intensity and sensitivity in the awake rat.

21 January 2018

1 reference

Antagonism of rat orexin receptors by almorexant attenuates central chemoreception in wakefulness in the active period of the diurnal cycle

21 January 2018

1 reference

Central chemosensitivity and the reaction theory

21 January 2018

1 reference

Proton-sensing G-protein-coupled receptors

21 January 2018

1 reference

Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration

21 January 2018

1 reference

Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat.

21 January 2018

1 reference

Purinergic signalling in the rostral ventro-lateral medulla controls sympathetic drive and contributes to the progression of heart failure following myocardial infarction in rats.

21 January 2018

1 reference

Restoration of hypoxic respiratory responses in the awake rat after carotid body denervation by sinus nerve section

21 January 2018

1 reference

Late-expiratory activity: emergence and interactions with the respiratory CpG.

21 January 2018

1 reference

A closed-loop model of the respiratory system: focus on hypercapnia and active expiration

21 January 2018

1 reference

Inhibitory input from slowly adapting lung stretch receptors to retrotrapezoid nucleus chemoreceptors

21 January 2018

1 reference

Serotonergic neurons activate chemosensitive retrotrapezoid nucleus neurons by a pH-independent mechanism.

21 January 2018

1 reference

Respiratory control by ventral surface chemoreceptor neurons in rats

21 January 2018

1 reference

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

21 January 2018

1 reference

Julius H. Comroe, Jr., distinguished lecture: central chemoreception: then ... and now.

21 January 2018

1 reference

Oxygen-sensing neurons in the central nervous system.

21 January 2018

1 reference

Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats

21 January 2018

1 reference

Cytoarchitecture and CO(2) sensitivity of Phox2b-positive Parafacial neurons in the newborn rat medulla

21 January 2018

1 reference

Active expiration induced by excitation of ventral medulla in adult anesthetized rats

21 January 2018

1 reference

Harvey Cushing and the regulation of blood pressure in giraffe, rat and man: introducing 'Cushing's mechanism'.

21 January 2018

1 reference

Sensing hypoxia: physiology, genetics and epigenetics

21 January 2018

1 reference

Peripheral chemoreceptors in health and disease.

21 January 2018

1 reference

Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P.

21 January 2018

1 reference

Breathing without CO(2) chemosensitivity in conditional Phox2b mutants.

21 January 2018

1 reference

Serotonin excitation of facial motoneurons: receptor subtype characterization.

21 January 2018

1 reference

Central neurogenic neuroprotection: central neural systems that protect the brain from hypoxia and ischemia.

21 January 2018

1 reference

Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney

21 January 2018

1 reference

PHOX2B immunolocalization of the candidate human retrotrapezoid nucleus

21 January 2018

1 reference

The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO₂

21 January 2018

1 reference

Expression of c-fos protein in brain: metabolic mapping at the cellular level

21 January 2018

1 reference

Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels

21 January 2018

1 reference

Brainstem respiratory networks: building blocks and microcircuits

21 January 2018

1 reference

Brainstem projections to the major respiratory neuron populations in the medulla of the cat.

21 January 2018

1 reference

Functions of the retrofacial nucleus in chemosensitivity and ventilatory neurogenesis

21 January 2018

1 reference

Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat.

21 January 2018

1 reference

Galanin is a selective marker of the retrotrapezoid nucleus in rats

21 January 2018

1 reference

Central neural organization and control of sympathetic nervous system in mammals

21 January 2018

1 reference

Central neural mechanisms mediating excitation of sympathetic neurons by hypoxia

21 January 2018

1 reference

Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats

21 January 2018

1 reference

Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apnoeic threshold in rats

21 January 2018

1 reference

GABAergic pump cells of solitary tract nucleus innervate retrotrapezoid nucleus chemoreceptors

21 January 2018

1 reference

The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysis

21 January 2018

1 reference

Serotonin neurons and central respiratory chemoreception: where are we now?

21 January 2018

1 reference

Genetic identification of an embryonic parafacial oscillator coupling to the preBötzinger complex

21 January 2018

1 reference

Denervation of Carotid Baro‐ and Chemoreceptors in Humans

21 January 2018

1 reference

Impaired CO2 sensitivity of astrocytes in a mouse model of Rett syndrome

21 January 2018

1 reference

Differences in respiratory changes and Fos expression in the ventrolateral medulla of rats exposed to hypoxia, hypercapnia, and hypercapnic hypoxia

21 January 2018

1 reference

TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons

21 January 2018

1 reference

Phox2b-expressing retrotrapezoid neurons are intrinsically responsive to H+ and CO2.

21 January 2018

1 reference

An official ATS clinical policy statement: Congenital central hypoventilation syndrome: genetic basis, diagnosis, and management

21 January 2018

1 reference

Astrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism

21 January 2018

1 reference

Regulation of ventral surface CO2/H+-sensitive neurons by purinergic signalling.

21 January 2018

1 reference

21 January 2018

1 reference

Respiratory neuroplasticity following carotid body denervation: Central and peripheral adaptations

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Lactate-mediated glia-neuronal signalling in the mammalian brain

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Respiratory rhythm generation in vivo

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

CO₂directly modulates connexin 26 by formation of carbamate bridges between subunits

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Control of breathing during exercise

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Central chemoreceptors: locations and functions

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Peripheral chemoreceptors: function and plasticity of the carotid body

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Pontine mechanisms of respiratory control

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Ventilatory responses to specific CNS hypoxia in sleeping dogs.

26 November 2018

1 reference

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Synaptic control of motoneuronal excitability.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

CO(2) microdialysis in retrotrapezoid nucleus of the rat increases breathing in wakefulness but not in sleep

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Ventilatory effects of glial dysfunction in a rat brain stem chemoreceptor region

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Carotid chemoreflex. Neural pathways and transmitters

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Medullary vasomotor activity and hypoxic sympathoexcitation in pentobarbital-anesthetized rats.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Retrotrapezoid nucleus glutamate injections: long-term stimulation of phrenic activity

26 November 2018

1 reference

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Rat retrotrapezoid nucleus iono- and metabotropic glutamate receptors and the control of breathing.

26 November 2018

1 reference

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The C1 area of the rostral ventrolateral medulla oblongata. A critical brainstem region for control of resting and reflex integration of arterial pressure.

26 November 2018

1 reference

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Respiratory activity in retrotrapezoid nucleus in cat.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Lesions in retrotrapezoid nucleus decrease ventilatory output in anesthetized or decerebrate cats

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Structure and function of the brain serotonin system

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Medullary CO2 chemoreceptor neuron identification by c-fos immunocytochemistry

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Topography of cat medullary ventral surface hypoxic acidification

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4799966

Bidirectional control of arteriole diameter by astrocytes

26 November 2018

1 reference

12 December 2020

Pre-Bötzinger complex functions as a central hypoxia chemosensor for respiration in vivo

1 reference

12 December 2020

Distribution of brainstem projections from spinal lamina I neurons in the cat and the monkey

1 reference

12 December 2020

Effect of hypercapnia on hypoxic ventilatory drive in carotid body-resected man

1 reference

12 December 2020

Activity of medullary serotonergic neurons in freely moving animals

1 reference

12 December 2020

O2-sensing after carotid chemodenervation: hypoxic ventilatory responsiveness and upregulation of tyrosine hydroxylase mRNA in brainstem catecholaminergic cells

1 reference

12 December 2020

Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO(2)

1 reference

12 December 2020

Responses of respiratory modulated and tonic units in the retrotrapezoid nucleus to CO2

1 reference

12 December 2020

Acute and chronic effects of carotid body denervation on ventilation and chemoreflexes in three rat strains

1 reference

12 December 2020

Congenital central hypoventilation and sleep state

1 reference

12 December 2020

ATP as a mediator of mammalian central CO2 chemoreception

1 reference

12 December 2020

Exercise hyperpnea and locomotion: parallel activation from the hypothalamus

1 reference

12 December 2020

The regulation of the lung-ventilation

1 reference

12 December 2020

Identifiers

DOI

10.1113/JP271480

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14 June 2017

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