(Q30306742)

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Intracellular signals that control cell proliferation in mammalian balance epithelia: key roles for phosphatidylinositol-3 kinase, mammalian target of rapamycin, and S6 kinases in preference to calcium, protein kinase C, and mitogen-activated [...]

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Europe PubMed Central

PubMed publication ID

16 June 2017

Intracellular signals that control cell proliferation in mammalian balance epithelia: key roles for phosphatidylinositol-3 kinase, mammalian target of rapamycin, and S6 kinases in preference to calcium, protein kinase C, and mitogen-activated protein kinase (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763828&resulttype=core&format=json

12 May 2020

1 reference

based on heuristic

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mireille montcouquiol

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763828&resulttype=core&format=json

12 May 2020

author name string

J T Corwin

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763828&resulttype=core&format=json

12 May 2020

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publication date

1 January 2001

1 reference

Europe PubMed Central

PubMed publication ID

16 June 2017

Journal of Neuroscience

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763828&resulttype=core&format=json

12 May 2020

21

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763828&resulttype=core&format=json

12 May 2020

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763828&resulttype=core&format=json

12 May 2020

570-580

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763828&resulttype=core&format=json

12 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6763828/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Phosphoinositide kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunopharmacology of rapamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activa

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The modular phosphorylation and activation of p70s6k.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C and lipid signaling for sustained cellular responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A synthetic inhibitor of the mitogen-activated protein kinase cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fish n' chicks: model recipes for hair-cell regeneration?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of phosphoinositide 3-kinase lipid products in cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transforming growth factor alpha with insulin stimulates cell proliferation in vivo in adult rat vestibular sensory epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear localization of p85s6k: functional requirement for entry into S phase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calphostin (UCN1028) and calphostin related compounds, a new class of specific and potent inhibitors of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of mitogen-activated protein kinase in freshly isolated rat hepatocytes by both a calcium- and a protein kinase C-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of p70 s6 kinase by kinase activity of FRAP in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of cell proliferation by fibroblast and insulin-like growth factors in pure rat inner ear epithelial cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An intracellular calcium signal activates p70 but not p90 ribosomal S6 kinase in liver epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proliferation in the auditory receptor epithelium mediated by a cyclic AMP-dependent signaling pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NDF/heregulin stimulates the phosphorylation of Her3/erbB3

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling through protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrastructural evidence for hair cell regeneration in the mammalian inner ear

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+ and protein kinase C-dependent mechanisms involved in gastrin-induced Shc/Grb2 complex formation and P44-mitogen-activated protein kinase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of the inner ear of the mouse: a radioautographic study of terminal mitoses

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An RT-PCR analysis of mRNA for growth factor receptors in damaged and control sensory epithelia of rat utricles

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inner ear hair cell regeneration in a mammal: identification of a triggering factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specificity within the EGF family/ErbB receptor family signaling network

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/11160436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-02-00570.2001

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763828&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763828&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763828&resulttype=core&format=json

12 May 2020

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