(Q30309900)

16 June 2017

title

Human Sir2 and the 'silencing' of p53 activity (English)

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16 June 2017

Jeffrey Smith

1

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16 June 2017

publication date

1 September 2002

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16 June 2017

published in

Trends in Cell Biology

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16 June 2017

volume

12

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16 June 2017

issue

9

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16 June 2017

page(s)

404-406

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Acetylation of histones and transcription-related factors

16 June 2017

cites work

1 reference

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7 January 2021

Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription

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7 January 2021

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

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https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902342-5

7 January 2021

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

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https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902342-5

7 January 2021

Negative control of p53 by Sir2alpha promotes cell survival under stress

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7 January 2021

The human histone deacetylase family

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7 January 2021

Enzymatic activities of Sir2 and chromatin silencing

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7 January 2021

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

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7 January 2021

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

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7 January 2021

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

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https://api.crossref.org/works/10.1016%2FS0962-8924%2802%2902342-5

7 January 2021

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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7 January 2021

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

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7 January 2021

Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions

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7 January 2021

Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

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Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

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7 January 2021

Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases

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7 January 2021

CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis i

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7 January 2021

Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism

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7 January 2021

Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation

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7 January 2021

Deacetylation of p53 modulates its effect on cell growth and apoptosis

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7 January 2021

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

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7 January 2021

Genetic pathways that regulate ageing in model organisms

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7 January 2021

Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.

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7 January 2021

p53 mutant mice that display early ageing-associated phenotypes

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7 January 2021

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

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7 January 2021

Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae

1 reference

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7 January 2021

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Identifiers

DOI

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16 June 2017

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