(Q30310364)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12506132%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

title

Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells (English)

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16 December 2019

1 reference

1

Danyelle M Townsend

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16 December 2019

author name string

Mei Deng

2

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16 December 2019

Lei Zhang

3

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16 December 2019

Maia G Lapus

4

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16 December 2019

Marie H Hanigan

5

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16 December 2019

publication date

1 January 2003

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12506132%20AND%20SRC:MED&resulttype=core&format=json

Journal of the American Society of Nephrology

16 December 2019

published in

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16 December 2019

volume

14

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16 December 2019

issue

1

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16 December 2019

page(s)

1-10

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Gamma-glutamyl transpeptidase accelerates tumor growth and increases the resistance of tumors to cisplatin in vivo

16 December 2019

cites work

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12 December 2020

Overexpression of the human 72 kDa heat shock protein in renal tubular cells confers resistance against oxidative injury and cisplatin toxicity.

1 reference

12 December 2020

Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)

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12 December 2020

Overexpression of glutathione S-transferase pi enhances the adduct formation of cisplatin with glutathione in human cancer cells

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12 December 2020

1 reference

12 December 2020

Preclinical perspectives on platinum resistance

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12 December 2020

Clinical perspectives on platinum resistance

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12 December 2020

Reduction of cisplatin nephrotoxicity by procainamide: does the formation of a cisplatin-procainamide complex play a role?

1 reference

12 December 2020

Role of mitochondrial dysfunction in S-(1,2-dichlorovinyl)-l-cysteine-induced apoptosis

1 reference

12 December 2020

Hepatic and renal toxicities associated with perchloroethylene

1 reference

12 December 2020

Gamma-glutamyl transpeptidase-deficient mice are resistant to the nephrotoxic effects of cisplatin

1 reference

12 December 2020

Co-purification of mitochondrial HSP70 and mature protein disulfide isomerase with a functional rat kidney high-M(r) cysteine S-conjugate beta-lyase

1 reference

12 December 2020

Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice

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12 December 2020

Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways.

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12 December 2020

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis

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12 December 2020

Regulation of the cellular stress response by reactive electrophiles. The role of covalent binding and cellular thiols in transcriptional activation of the 70-kilodalton heat shock protein gene by nephrotoxic cysteine conjugates

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12 December 2020

Control of the nephrotoxicity of cisplatin by clinically used sulfur-containing compounds

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12 December 2020

Nephrotoxicity of the glutathione and cysteine conjugates of 2-bromo-2-chloro-1,1-difluoroethene.

1 reference

12 December 2020

A feasibility study of high-dose cisplatin and 5-fluorouracil with glutathione protection in the treatment of advanced colorectal cancer

1 reference

12 December 2020

Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents

1 reference

12 December 2020

Reaction of cis- and trans-[PtCl2(NH3)2] with reduced glutathione inside human red blood cells, studied by 1H and 15N-[1H] DEPT NMR

1 reference

12 December 2020

Quiescent LLC-PK1 cells as a model for cis-diamminedichloroplatinum(II) nephrotoxicity and modulation by thiol rescue agents

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12 December 2020

Intracellular metabolites of cisplatin in the rat kidney

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12 December 2020

Protective effect of reduced glutathione against cisplatin-induced renal and systemic toxicity and its influence on the therapeutic activity of the antitumor drug

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12 December 2020

Improved use of buthionine sulfoximine to prevent cisplatin nephrotoxicity in rats

1 reference

12 December 2020

N-acetyl S-(1,2-dichlorovinyl)-L-cysteine produces a similar toxicity to S-(1,2-dichlorovinyl)-L-cysteine in rabbit renal slices: differential transport and metabolism

1 reference

12 December 2020

Gamma-glutamyl transpeptidase--its role in hepatocarcinogenesis

1 reference

12 December 2020

Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity

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12 December 2020

Differential effect of cis-platinum (cis-diamminedichloroplatinum) on regulation of liver and kidney haem and haemoprotein metabolism. Possible involvement of gamma-glutamyl-cycle enzymes

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12 December 2020

The transport of S-cysteine conjugates in LLC-PK1 cells and its role in toxicity.

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12 December 2020

Inhibition of cisplatin-induced nephrotoxicity in rats by buthionine sulfoximine, a glutathione synthesis inhibitor

1 reference

12 December 2020

Differential toxicity as a result of apical and basolateral treatment of LLC-PK1 monolayers with S-(1,2,3,4,4-pentachlorobutadienyl)glutathione and N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine

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12 December 2020

The role of glutathione conjugate metabolism and cysteine conjugate beta-lyase in the mechanism of S-cysteine conjugate toxicity in LLC-PK1 cells

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12 December 2020

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12 December 2020

Clinical and pharmacological studies with cis-diamminedichloroplatinum (II)

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12 December 2020

The development of gamma-glutamyltransferase in a pig renal-epithelial-cell line in vitro. Relationship to amino acid transport

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12 December 2020

Alkaline phosphatase and gamma-glutamyl transpeptidase as polarization markers during the organization of LLC-PK1 cells into an epithelial membrane

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12 December 2020

Effect of diethyldithiocarbamate rescue on tumor response to cis-platinum in a rat model

1 reference

12 December 2020

Specificity of a particulate rat renal peptidase and its localization along with other enzymes of mercapturic acid synthesis

1 reference

12 December 2020

Preclinical studies on toxicity, antitumour activity and pharmacokinetics of cisplatin and three recently developed derivatives.

1 reference

12 December 2020

Renal processing of glutathione conjugates. Role in nephrotoxicity

1 reference

12 December 2020

Cisplatin metabolites in plasma, a study of their pharmacokinetics and importance in the nephrotoxic and antitumour activity of cisplatin

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12 December 2020

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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12 December 2020

In vivo and in vitro nephrotoxicity of the cysteine conjugate of hexachlorobutadiene

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12 December 2020

Nephrotoxic potential of cis-diamminedichloroplatinum and four analogs in male Fischer 344 rats

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12 December 2020

Mechanism of cis-platinum nephrotoxicity: II. Morphologic observations

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12 December 2020

Acute and chronic cisplatin nephropathy in rats

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12 December 2020

Glutamine transaminase K is not a major cysteine S-conjugate beta-lyase of rat kidney mitochondria: evidence that a high-molecular weight enzyme fulfills this role.

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12 December 2020

Characterization of cisplatin-glutathione adducts by liquid chromatography-mass spectrometry. Evidence for their formation in vitro but not in vivo after concomitant administration of cisplatin and glutathione to rats anc cancer patients

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12 December 2020

Mitochondrial HSP60 (P1 protein) and a HSP70-like protein (mortalin) are major targets for modification during S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-induced nephrotoxicity

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12 December 2020

Inhibition of gamma-glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity.

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12 December 2020

Cisplatin-induced renal toxicity and toxicity-modulating strategies: a review

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12 December 2020

Protection against cisplatin-induced nephrotoxicity in the rat by inducers and an inhibitor of glutathione S-transferase

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12 December 2020

Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate beta-lyase pathway

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12 December 2020

Extracellular glutathione is a source of cysteine for cells that express gamma-glutamyl transpeptidase

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12 December 2020

Nephrotoxicity and hydration management for cisplatin, carboplatin, and ormaplatin

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12 December 2020

Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance

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12 December 2020

Isolation and expression of a cDNA coding for rat kidney cytosolic cysteine conjugate beta-lyase

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12 December 2020

Insights into mechanisms of cisplatin resistance and potential for its clinical reversal

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12 December 2020

Transfection of glutathione S-transferase (GST)-pi antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide

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12 December 2020

Immunohistochemical detection of gamma-glutamyl transpeptidase in normal human tissue

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12 December 2020

Effect of the antiarrhythmic drug procainamide on the toxicity and antitumor activity of cis-diamminedichloroplatinum(II)

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12 December 2020

The effect of methylprednisolone on platinum kinetics and urinary enzyme excretion following intravenous cisplatin in vivo and on the growth inhibition of LLC-PK1 cells by cisplatin in vitro

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12 December 2020

Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosis

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12 December 2020

Relationship between pharmacokinetics of unchanged cisplatin and nephrotoxicity after intravenous infusions of cisplatin to cancer patients

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12 December 2020

Kinetic analysis of the cis-diamminedichloroplatinum(II)--cysteine reaction: implications to the extent of platinum--DNA binding.

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12 December 2020

Stable transfection of LLC-PK1 cells with human microsomal glutathione S-transferase gene increases haloalkene glutathione S-conjugate formation and cytotoxicity

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12 December 2020

Mechanisms of cysteine S-conjugate beta-lyases

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12 December 2020

Glutathione-dependent bioactivation of haloalkenes

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12 December 2020

Pharmacokinetics of cisplatin with and without amifostine in tumour-bearing nude mice

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12 December 2020

gamma-Glutamyl transpeptidase, a glutathionase: its expression and function in carcinogenesis

1 reference

12 December 2020

Immunohistochemical staining for glutathione S-transferase predicts response to platinum-based chemotherapy in head and neck cancer

1 reference

12 December 2020

In vitro reversal of glutathione-S-transferase-mediated resistance in canine osteosarcoma (COS31) cells

1 reference

12 December 2020

10.1097/01.ASN.0000042803.28024.92

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12506132%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12506132%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

PubMed publication ID

12506132

1 reference