(Q30319221)

17 June 2017

title

Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors (English)

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17 June 2017

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Ingo Bauer

5

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Rene Meier

Rene Meier

3

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Manfred Jung

Manfred Jung

6

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Wolfgang Sippl

Wolfgang Sippl

7

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Patrick Trojer

4

Patrick Trojer

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17 June 2017

Ralf Heinke

1

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17 June 2017

Astrid Spannhoff

2

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17 June 2017

publication date

1 January 2009

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17 June 2017

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17 June 2017

volume

4

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17 June 2017

issue

1

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17 June 2017

page(s)

69-77

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Translating the Histone Code

17 June 2017

cites work

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Arginine methylation an emerging regulator of protein function

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Control of CBP co-activating activity by arginine methylation

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Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein.

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Small molecule regulators of protein arginine methyltransferases

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A glycine-arginine domain in control of the human MRE11 DNA repair protein

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Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.

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Protein arginine-methyltransferase-dependent oncogenesis

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Histone Deacetylase Inhibitors

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The antifungal antibiotic sinefungin as a ver y active inhibitor of methyltransferases and of the transformation of chick embryo fibroblasts by rous sarcoma virus

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Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

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Target-based approach to inhibitors of histone arginine methyltransferases

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A novel arginine methyltransferase inhibitor with cellular activity

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7 January 2021

Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations

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epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.

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Virtual screening of chemical libraries

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Generation of a homology model of the human histamine H3 receptor for ligand docking and pharmacophore-based screening

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Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode

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Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of Its Binding to Substrate Peptides

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7 January 2021

Crystal structure of the conserved core of protein arginine methyltransferase PRMT3

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The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing.

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Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains

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Benchmarking sets for molecular docking

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7 January 2021

Protein-ligand docking accounting for receptor side chain and global flexibility in normal modes: evaluation on kinase inhibitor cross docking

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7 January 2021

In pursuit of virtual lead optimization: the role of the receptor structure and ensembles in accurate docking

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7 January 2021

Virtual Screening for Selective Allosteric mGluR1 Antagonists and Structure–Activity Relationship Investigations for Coumarine Derivatives

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7 January 2021

Virtual screening approaches for the identification of non-lipid autotaxin inhibitors

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7 January 2021

Identification of nonpeptide CCR5 receptor agonists by structure-based virtual screening

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7 January 2021

Screening drug-like compounds by docking to homology models: a systematic study.

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7 January 2021

Target flexibility: an emerging consideration in drug discovery and design

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7 January 2021

LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters

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7 January 2021

Development and validation of a genetic algorithm for flexible docking

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7 January 2021

Histone methyltransferases in Aspergillus nidulans: evidence for a novel enzyme with a unique substrate specificity.

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7 January 2021

Identifiers

DOI

10.1002/CMDC.200800301

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17 June 2017

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