(Q30319326)

17 June 2017

title

Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases (English)

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17 June 2017

Livia Böhme

1

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17 June 2017

Torsten Hoffmann

2

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17 June 2017

Susanne Manhart

3

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17 June 2017

Raik Wolf

4

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17 June 2017

Hans-Ulrich Demuth

5

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17 June 2017

language of work or name

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1 August 2008

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17 June 2017

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17 June 2017

volume

389

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17 June 2017

issue

8

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17 June 2017

page(s)

1055-1066

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Isoaspartate residues dramatically influence substrate recognition and turnover by proteases

17 June 2017

cites work

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

The role of amyloid beta peptide 42 in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1515%2FBC.2008.125

Neurohormonal Signaling Pathways and the Regulation of Alzheimer beta-Amyloid Precursor Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Fragmentation of isoaspartyl peptides and proteins by carboxypeptidase Y: release of isoaspartyl dipeptides as a result of internal and external cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Abeta40 inhibits amyloid deposition in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Isolation, chemical characterization, and quantitation of A beta 3-pyroglutamyl peptide from neuritic plaques and vascular amyloid deposits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

beta-amyloid is different in normal aging and in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Deamidation and isoaspartate formation in proteins: unwanted alterations or surreptitious signals?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s).

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Isoaspartate formation and neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Biological significance of isoaspartate and its repair system

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Ca2+-free calmodulin and calmodulin damaged by in vitro aging are selectively degraded by 26 S proteasomes without ubiquitination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Employing a superior BACE1 cleavage sequence to probe cellular APP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Age-dependent axonal degeneration in an Alzheimer mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

Therapeutic strategies of Alzheimer's disease through manipulation of A? metabolism: a focus on A?-degrading peptidase, neprilysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2008.125

21 January 2018

Identifiers

DOI

10.1515/BC.2008.125

1 reference

17 June 2017

1 reference