(Q30328122)

18 June 2017

title

Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4. (English)

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18 June 2017

Richter W

1

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18 June 2017

Unciuleac L

2

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18 June 2017

Hermsdorf T

3

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18 June 2017

Kronbach T

4

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18 June 2017

Dettmer D

5

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18 June 2017

publication date

1 April 2001

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18 June 2017

number of pages

11

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inferred from page(s)

published in

Cellular Signalling

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18 June 2017

volume

13

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18 June 2017

issue

4

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18 June 2017

page(s)

287-297

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Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes

18 June 2017

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Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase

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Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase

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Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)

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Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition

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A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

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Effects of rolipram on responses to acute and chronic antigen exposure in monkeys.

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Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP-specific phosphodiesterase: comparison with rolipram

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The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4.

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PDE isoenzymes as targets for anti-asthma drugs

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Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret

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Human recombinant phosphodiesterase 4B2B binds (R)-rolipram at a single site with two affinities

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Detailed characterization of a purified type 4 phosphodiesterase, HSPDE4B2B: differentiation of high- and low-affinity (R)-rolipram binding

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Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases

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7 January 2021

Dual inhibition of human type 4 phosphodiesterase isostates by (R, R)-(+/-)-methyl 3-acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate

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7 January 2021

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

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7 January 2021

Activation of the cAMP-specific phosphodiesterase PDE4D3 by phosphorylation. Identification and function of an inhibitory domain

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7 January 2021

UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions.

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Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation

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The cAMP-specific phosphodiesterase PDE4D3 is regulated by phosphatidic acid binding. Consequences for cAMP signaling pathway and characterization of a phosphatidic acid binding site

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7 January 2021

Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition

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7 January 2021

The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram

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7 January 2021

Refolding, purification, and characterization of human recombinant PDE4A constructs expressed in Escherichia coli

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7 January 2021

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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7 January 2021

Combined effects of insulin and dexamethasone on cyclic AMP phosphodiesterase 3 and glycogen metabolism in cultured rat hepatocytes

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7 January 2021

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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7 January 2021

Role of conserved histidines in catalytic activity and inhibitor binding of human recombinant phosphodiesterase 4A

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7 January 2021

Identification of inhibitor specificity determinants in a mammalian phosphodiesterase

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7 January 2021

Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells

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7 January 2021

Potential roles of conserved amino acids in the catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase

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7 January 2021

Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds

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7 January 2021

Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity

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7 January 2021

Critical role of conserved histidine pairs HNXXH and HDXXH in recombinant human phosphodiesterase 4A

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7 January 2021

Conformational difference between PDE4 apoenzyme and holoenzyme

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7 January 2021

10.1016/S0898-6568(01)00150-4

Identifiers

DOI

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18 June 2017

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