(Q30350628)

20 June 2017

1 reference

title

NMR spectroscopy and protein structure determination: applications to drug discovery and development. (English)

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protein structure determination

20 June 2017

1 reference

0 references

David Wishart

1

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publication date

1 April 2005

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Current Pharmaceutical Biotechnology

20 June 2017

published in

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20 June 2017

volume

6

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20 June 2017

issue

2

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20 June 2017

page(s)

105-120

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Rapid and accurate calculation of protein 1H, 13C and 15N chemical shifts

20 June 2017

cites work

2 references

5 May 2024

https://opencitations.net/index/api/v1/citations/10.1023/A:1023812930288

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Automated 1H and 13C chemical shift prediction using the BioMagResBank

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

NMR analysis of a 900K GroEL GroES complex

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Protein backbone structure determination using only residual dipolar couplings from one ordering medium.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

MUSIC and aromatic residues: amino acid type-selective (1)H-(15)N correlations, III.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

NMR and structural genomics

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Torsion angle dynamics for NMR structure calculation with the new program DYANA

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

GFT NMR, a new approach to rapidly obtain precise high-dimensional NMR spectral information.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

A highly efficient and robust cell-free protein synthesis system prepared from wheat embryos: plants apparently contain a suicide system directed at ribosomes

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Cell-free production and stable-isotope labeling of milligram quantities of proteins

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

New approaches to structure determination by NMR spectroscopy

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Optimization of protein solubility and stability for protein nuclear magnetic resonance

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Molecular modeling and computer aided drug design. Examples of their applications in medicinal chemistry

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

The button test: a small scale method using microdialysis cells for assessing protein solubility at concentrations suitable for NMR

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Determination of three-bond scalar coupling between 13C' and 1H(alpha) in proteins using an iHN(CA),CO(alpha/beta-J-COHA) experiment.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Automated NMR determination of protein backbone dihedral angles from cross-correlated spin relaxation

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Assignment of the side-chain proton and carbon-13 resonances of interleukin-1.beta. using double- and triple-resonance heteronuclear three-dimensional NMR spectroscopy

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

CLOUDS, a protocol for deriving a molecular proton density via NMR.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

VADAR: a web server for quantitative evaluation of protein structure quality

2 references

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

5 May 2024

https://opencitations.net/index/api/v1/citations/10.1093/NAR/GKG565

A novel medium for expression of proteins selectively labeled with 15N-amino acids in Spodoptera frugiperda (Sf9) insect cells

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Automatic determination of protein backbone resonance assignments from triple resonance nuclear magnetic resonance data

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Exploring the limits of precision and accuracy of protein structures determined by nuclear magnetic resonance spectroscopy.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Genetic tools for selective labeling of proteins with alpha-15N-amino acids

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Structural study of the N-terminal domain of the alpha subunit of Escherichia coli RNA polymerase solubilized with non-denaturing detergents

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Discovering high-affinity ligands for proteins: SAR by NMR

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Structure/function of human herpesvirus-8 MIP-II (1-71) and the antagonist N-terminal segment (1-10)

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Production of large quantities of isotopically labeled protein in Pichia pastoris by fermentation

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

De novo determination of protein backbone structure from residual dipolar couplings using Rosetta

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Binding of ethidium to DNA measured using a 2D diffusion-modulated gradient COSY NMR experiment

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Structure-based minimization of transforming growth factor-alpha (TGF-alpha) through NMR analysis of the receptor-bound ligand. Design, solution structure, and activity of TGF-alpha 8-50.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

An NMR-based model of the ubiquitin-bound human ubiquitin conjugation complex Mms2.Ubc13. The structural basis for lysine 63 chain catalysis

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Mapping protein-protein interactions in solution by NMR spectroscopy

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

A comparison of inverse-detected heteronuclear NMR performance: conventional vs cryogenic microprobe performance.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

NMR - this other method for protein and nucleic acid structure determination.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Use of chemical shifts and coupling constants in nuclear magnetic resonance structural studies on peptides and proteins

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Unmasking ligand binding motifs: identification of a chemokine receptor motif by NMR studies of antagonist peptides

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Characterization of the ATP-binding domain of the sarco(endo)plasmic reticulum Ca(2+)-ATPase: probing nucleotide binding by multidimensional NMR.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Designing decoys for chemokine-chemokine receptor interaction

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Progress on the two-dimensional filter diagonalization method. An efficient doubling scheme for two-dimensional constant-time NMR.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Three-dimensional NMR spectroscopy of a protein in solution

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

LC-NMR-MS in drug discovery

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

A robust and cost-effective method for the production of Val, Leu, Ile (delta 1) methyl-protonated 15N-, 13C-, 2H-labeled proteins

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Automated backbone assignment of labeled proteins using the threshold accepting algorithm

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

A computational method for NMR-constrained protein threading.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Applications of NMR in drug discovery

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Cell-free synthesis and amino acid-selective stable isotope labeling of proteins for NMR analysis.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Chemical ligation of folded recombinant proteins: segmental isotopic labeling of domains for NMR studies

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Determination of backbone angle psi in proteins using a TROSY-based alpha/beta-HN(CO)CA-J experiment.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Measurement of homo- and heteronuclear J couplings from quantitative J correlation.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Protein three-dimensional structure determination and sequence-specific assignment of 13C and 15N-separated NOE data. A novel real-space ab initio approach

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Distance geometry and related methods for protein structure determination from NMR data

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Filamentous bacteriophage for aligning RNA, DNA, and proteins for measurement of nuclear magnetic resonance dipolar coupling interactions

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Hydrogen exchange nuclear magnetic resonance spectroscopy mapping of antibody epitopes on the house dust mite allergen Der p 2.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Improved segmental isotope labeling of proteins and application to a larger protein

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Perspectives of immobilized-metal affinity chromatography

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Domain orientation and dynamics in multidomain proteins from residual dipolar couplings

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Two-dimensional spin echo correlated spectroscopy (SECSY) for 1H NMR studies of biological macromolecules

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Direct measurement of angles between bond vectors in high-resolution NMR.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

1H-15N heteronuclear NMR studies of Escherichia coli thioredoxin in samples isotopically labeled by residue type.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

1H(C) and 1H(N) total NOE correlations in a single 3D NMR experiment. 15N and 13C time-sharing in t1 and t2 dimensions for simultaneous data acquisition.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

New methods for fast multidimensional NMR.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Use of chemical shifts in macromolecular structure determination

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Probing multiple effects on 15N, 13C alpha, 13C beta, and 13C' chemical shifts in peptides using density functional theory

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Microdrop screening: a rapid method to optimize solvent conditions for NMR spectroscopy of proteins

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

High-resolution NMR of encapsulated proteins dissolved in low-viscosity fluids

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Use of nuclear Overhauser effect in the study of peptides and proteins

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Interpretation of chemical shifts and coupling constants in macromolecules

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

NMR spectroscopy of large molecules and multimolecular assemblies in solution.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

The direct determination of protein structure by NMR without assignment.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Completeness of NOEs in protein structure: a statistical analysis of NMR.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Weak alignment offers new NMR opportunities to study protein structure and dynamics.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

A relational database for sequence-specific protein NMR data

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Automated analysis of NMR assignments and structures for proteins.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

The Cap-binding protein eIF4E promotes folding of a functional domain of yeast translation initiation factor eIF4G1.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Nmr probes of molecular dynamics: overview and comparison with other techniques

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Structure calculation of biological macromolecules from NMR data.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Protein dynamics from NMR.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

NMR tools for biotechnology

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Practical introduction to theory and implementation of multinuclear, multidimensional nuclear magnetic resonance experiments

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Combined use of proton-proton overhauser enhancements and a distance geometry algorithm for determination of polypeptide conformations. Application to micelle-bound glucagon

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

High-throughput crystallography for lead discovery in drug design.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Relationship between nuclear magnetic resonance chemical shift and protein secondary structure

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

WHAT IF: a molecular modeling and drug design program

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Calcium-induced dimerization of troponin C: mode of interaction and use of trifluoroethanol as a denaturant of quaternary structure

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

RefDB: a database of uniformly referenced protein chemical shifts

2 references

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

5 May 2024

https://opencitations.net/index/api/v1/citations/10.1023/A:1022836027055

Effective energy function for proteins in solution

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

A novel approach for sequential assignment of 1H, 13C, and 15N spectra of proteins: heteronuclear triple-resonance three-dimensional NMR spectroscopy. Application to calmodulin

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

A practical method for uniform isotopic labeling of recombinant proteins in mammalian cells

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Recombinant protein expression in Pichia pastoris

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

The 13C chemical-shift index: a simple method for the identification of protein secondary structure using 13C chemical-shift data

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Enhanced protein fold recognition using secondary structure information from NMR.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Automated assignment and 3D structure calculations using combinations of 2D homonuclear and 3D heteronuclear NOESY spectra

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Smartnotebook: a semi-automated approach to protein sequential NMR resonance assignments

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

A new vector for high-throughput, ligation-independent cloning encoding a tobacco etch virus protease cleavage site

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Theoretical and computational advances in biomolecular NMR spectroscopy

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Application of 1H NMR chemical shifts to measure the quality of protein structures

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

An efficient and cost-effective isotope labeling protocol for proteins expressed in Escherichia coli

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Inteins: structure, function, and evolution

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Nobel Lecture. Nuclear magnetic resonance Fourier transform spectroscopy

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Four-dimensional NMR spectroscopy of a 723-residue protein: chemical shift assignments and secondary structure of malate synthase g.

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Pulsed-field gradients: theory and practice

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Protein expression systems for structural genomics and proteomics

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

An empirical energy function for threading protein sequence through the folding motif

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

The use of 2H, 13C, 15N multidimensional NMR to study the structure and dynamics of proteins

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

The Protein Data Bank

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Automated protein fold determination using a minimal NMR constraint strategy

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Protein NMR structure determination with automated NOE-identification in the NOESY spectra using the new software ATNOS

1 reference

5 May 2024

https://opencitations.net/index/api/v1/references/10.2174/1389201053642367

Identifiers

DOI

10.2174/1389201053642367

1 reference

20 June 2017

1 reference