(Q30354782)

14 October 2017

On the role of aggregation prone regions in protein evolution, stability, and enzymatic catalysis: insights from diverse analyses. (English)

1 reference

14 October 2017

0 references

Patrick M Buck

1

1 reference

14 October 2017

Sandeep Kumar

series ordinal

2

1 reference

14 October 2017

Satish K Singh

series ordinal

3

1 reference

14 October 2017

language of work or name

1 reference

17 October 2013

1 reference

PLOS Computational Biology

14 October 2017

1 reference

14 October 2017

9

1 reference

14 October 2017

10

1 reference

14 October 2017

e1003291

1 reference

Creative Commons Attribution 4.0 International

14 October 2017

start time

17 October 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Metal ion leachates and the physico-chemical stability of biotherapeutic drug products

1 reference

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β(2)-microglobulin amyloidosis

3 June 2018

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Effective inter-residue contact definitions for accurate protein fold recognition

3 June 2018

1 reference

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Aggregation gatekeepers modulate protein homeostasis of aggregating sequences and affect bacterial fitness.

3 June 2018

1 reference

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Mechanisms of intramolecular communication in a hyperthermophilic acylaminoacyl peptidase: a molecular dynamics investigation

3 June 2018

1 reference

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Structure-based design of supercharged, highly thermoresistant antibodies

3 June 2018

1 reference

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The distribution of ligand-binding pockets around protein-protein interfaces suggests a general mechanism for pocket formation

3 June 2018

1 reference

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Proteome folding and aggregation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Quality control compartments coming of age.

3 June 2018

1 reference

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Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: implication for protein aggregation and immune response.

3 June 2018

1 reference

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Protein solubility and protein homeostasis: a generic view of protein misfolding disorders

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Aggregation in protein-based biotherapeutics: computational studies and tools to identify aggregation-prone regions

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Computational methods for identification of functional residues in protein structures

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Molecular chaperones in protein folding and proteostasis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

An evolutionary trade-off between protein turnover rate and protein aggregation favors a higher aggregation propensity in fast degrading proteins

3 June 2018

1 reference

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Proteome-level interplay between folding and aggregation propensities of proteins.

3 June 2018

1 reference

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Amyloidogenic sequences in native protein structures

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Design of therapeutic proteins with enhanced stability.

3 June 2018

1 reference

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Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Protein sequences encode safeguards against aggregation.

3 June 2018

1 reference

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The formation of amyloid fibrils from proteins in the lysozyme family

3 June 2018

1 reference

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Data growth and its impact on the SCOP database: new developments

3 June 2018

1 reference

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The distribution of residues in a polypeptide sequence is a determinant of aggregation optimized by evolution.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Supercharging proteins can impart unusual resilience

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Atomic structures of amyloid cross-beta spines reveal varied steric zippers

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

DisProt: the Database of Disordered Proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

The 3D profile method for identifying fibril-forming segments of proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Protein aggregation and amyloidosis: confusion of the kinds?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Organism complexity anti-correlates with proteomic beta-aggregation propensity

3 June 2018

1 reference

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Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

A comparative study of the relationship between protein structure and beta-aggregation in globular and intrinsically disordered proteins.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case

3 June 2018

1 reference

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3 June 2018

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UniProt: the Universal Protein knowledgebase

3 June 2018

1 reference

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Multiple sequence alignment with the Clustal series of programs

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Kinetic partitioning of protein folding and aggregation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Oxygen access to the active site of cholesterol oxidase through a narrow channel is gated by an Arg-Glu pair

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Protein folding and function: the N-terminal fragment in adenylate kinase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Sequence complexity of disordered protein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

3 June 2018

The Protein Data Bank

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Knowledge-based protein secondary structure assignment

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798281

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

3 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

The PASTA server for protein aggregation prediction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

AGGRESCAN: method, application, and perspectives for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

Potential aggregation-prone regions in complementarity-determining regions of antibodies and their contribution towards antigen recognition: a computational analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

A relationship between mRNA expression levels and protein solubility in E. coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

How evolutionary pressure against protein aggregation shaped chaperone specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

Prediction of protein binding regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

How do thermophilic proteins resist aggregation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

Chemical biology: More charges against aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

Coupling of aggregation and immunogenicity in biotherapeutics: T- and B-cell immune epitopes may contain aggregation-prone regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

Insights into the potential aggregation liabilities of the b12 Fab fragment via elevated temperature molecular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

Impact of deglycosylation and thermal stress on conformational stability of a full length murine IgG2a monoclonal antibody: observations from molecular dynamics simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

Familial amyloidotic polyneuropathy type IV – gelsolin amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

Prediction of the Absolute Aggregation Rates of Amyloidogenic Polypeptide Chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003291

Computational methods to predict therapeutic protein aggregation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24146608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Relationship between potential aggregation-prone regions and HLA-DR-binding T-cell immune epitopes: implications for rational design of novel and follow-on therapeutic antibodies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24146608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PCBI.1003291

1 reference

14 October 2017

journals/ploscb/BuckKS13

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

14 October 2017

PubMed publication ID

24146608

1 reference