(Q43446354)

English

Potential aggregation-prone regions in complementarity-determining regions of antibodies and their contribution towards antigen recognition: a computational analysis

scientific article published on 27 April 2010

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

Potential aggregation-prone regions in complementarity-determining regions of antibodies and their contribution towards antigen recognition: a computational analysis (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

1 reference

based on heuristic

inferred from title

author name string

Xiaoling Wang

1

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

Satish K Singh

2

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

Sandeep Kumar

3

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

publication date

27 April 2010

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

27

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

1512-1529

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

Comparison of protein-protein interactions in serine protease-inhibitor and antibody-antigen complexes: implications for the protein docking problem

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0143-5

21 January 2018

Structure and Thermodynamics of Antigen Recognition by Antibodiesa

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0143-5

21 January 2018

The yeast prion Ure2p native-like assemblies are toxic to mammalian cells regardless of their aggregation state.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous fibril formation by polyalanines; discontinuous molecular dynamics simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bacterial inclusion bodies contain amyloid-like structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparative study of the relationship between protein structure and beta-aggregation in globular and intrinsically disordered proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generic hydrophobic residues are sufficient to promote aggregation of the Alzheimer's Abeta42 peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Principles of protein-protein recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assembly of IgH CDR3: Mechanism, Regulation, and Influence on Antibody Diversity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of amyloid fibril-forming segments based on structure and residue-based statistical potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Announcing the worldwide Protein Data Bank

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 3D profile method for identifying fibril-forming segments of proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Replica exchange molecular dynamics simulations of amyloid peptide aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of amyloid fibril-forming segments based on a support vector machine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Principles of protein-protein interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissecting alpha-helices: position-specific analysis of alpha-helices in globular proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in protein therapeutics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation-prone motifs in human immunoglobulin G.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atomistic simulations of the effects of polyglutamine chain length and solvent quality on conformational equilibria and spontaneous homodimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed mutagenesis to probe protein folding: evidence that the formation and aggregation of a bovine growth hormone folding intermediate are dissociable processes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An amyloid-forming segment of beta2-microglobulin suggests a molecular model for the fibril

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen bonding in globular proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anatomy of hot spots in protein interfaces

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-like features of polyglutamine aggregates and their assembly kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein sequences encode safeguards against aggregation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-antigen interactions: contact analysis and binding site topography.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in electrostatic properties at antibody-antigen binding sites: implications for specificity and cross-reactivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of therapeutic proteins with enhanced stability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformations of immunoglobulin hypervariable regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The atomic structure of protein-protein recognition sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessing the role of aromatic residues in the amyloid aggregation of human muscle acylphosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insight into the structure of amyloid fibrils from the analysis of globular proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A molecular dynamics approach to the structural characterization of amyloid aggregation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dataset of protein-protein interfaces generated with a sequence-order-independent comparison technique

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Role for Protein Misfolding in Immunogenicity of Biopharmaceuticals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein aggregation in silico.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-antigen interactions: new structures and new conformational changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The distribution of residues in a polypeptide sequence is a determinant of aggregation optimized by evolution.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple physical model for binding energy hot spots in protein-protein complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation-resistant domain antibodies selected on phage by heat denaturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computational design of antibody-affinity improvement beyond in vivo maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the cross-beta spine of amyloid-like fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computational models for the prediction of polypeptide aggregation propensity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineered antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rationalization of the effects of mutations on peptide and protein aggregation rates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early kinetics of amyloid fibril formation reveals conformational reorganisation of initial aggregates

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and thermodynamics of antigen recognition by antibodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of protein aggregates: an immunologic perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simulations as analytical tools to understand protein aggregation and predict amyloid conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein aggregation and bioprocessing

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interpretation of protein structures: Estimation of static accessibility

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural selection against protein aggregation on self-interacting and essential proteins in yeast, fly, and worm

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the minimal amyloid-forming fragment of the islet amyloid polypeptide. An experimental support for the key role of the phenylalanine residue in amyloid formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Yeast prions and their prion-forming domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of aggregation-prone regions in structured proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide aggregation in neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical safety evaluation of monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of "hot spots" of aggregation in disease-linked polypeptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-affinity single-domain binding proteins with a binary-code interface

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural Insights into the Role of Mutations in Amyloidogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent atomic models of amyloid fibril structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Competition between folding, native-state dimerisation and amyloid aggregation in beta-lactoglobulin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How evolutionary pressure against protein aggregation shaped chaperone specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The generalized Born/volume integral implicit solvent model: estimation of the free energy of hydration using London dispersion instead of atomic surface area

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic partitioning of protein folding and aggregation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stability of protein pharmaceuticals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20422267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11095-010-0143-5

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 November 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q43446354&oldid=2086165145"