(Q30362738)

14 September 2017

Ethical alternatives to experiments with novel potential pandemic pathogens. (English)

1 reference

14 September 2017

0 references

0 references

1

Marc Lipsitch

1 reference

14 September 2017

Alison P Galvani

2

1 reference

PMC publication ID

4028196

14 September 2017

language of work or name

English

0 references

publication date

20 May 2014

1 reference

14 September 2017

1 reference

14 September 2017

11

1 reference

14 September 2017

5

1 reference

14 September 2017

e1001646

1 reference

Creative Commons Attribution 4.0 International

14 September 2017

start time

20 May 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Airborne transmission of highly pathogenic H7N1 influenza virus in ferrets

1 reference

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Flu season: An interview with Jeffery K. Taubenberger, Chief of the Viral Pathogenesis and Evolution Section at the US National Institute of Allergy and Infectious Diseases

3 June 2018

1 reference

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Containing the accidental laboratory escape of potential pandemic influenza viruses

3 June 2018

1 reference

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Novel H7N9 influenza virus shows low infectious dose, high growth rate, and efficient contact transmission in the guinea pig model

3 June 2018

1 reference

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Pandemic influenza viruses: time to recognize our inability to predict the unpredictable and stop dangerous gain-of-function experiments.

3 June 2018

1 reference

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"Inconvenient truths" in the pursuit of scientific knowledge and public health

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Influenza virus hemagglutinin stalk-based antibodies and vaccines

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Limited airborne transmission of H7N9 influenza A virus between ferrets

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Considerations regarding appropriate sample size for conducting ferret transmission experiments

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

H7N9 influenza viruses are transmissible in ferrets by respiratory droplet.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

The effect of the PB2 mutation 627K on highly pathogenic H5N1 avian influenza virus is dependent on the virus lineage.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Glycan receptor binding of the influenza A virus H7N9 hemagglutinin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Pandemic influenza viruses--hoping for the road not taken

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Pandemic influenza planning, United States, 1978-2008.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Stability-mediated epistasis constrains the evolution of an influenza protein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Synthetic generation of influenza vaccine viruses for rapid response to pandemics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Comparison of the levels of infectious virus in respirable aerosols exhaled by ferrets infected with influenza viruses exhibiting diverse transmissibility phenotypes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

The universal epitope of influenza A viral neuraminidase fundamentally contributes to enzyme activity and viral replication

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

H5N1 hybrid viruses bearing 2009/H1N1 virus genes transmit in guinea pigs by respiratory droplet

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Guiding outbreak management by the use of influenza A(H7Nx) virus sequence analysis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Lipid tail protrusion in simulations predicts fusogenic activity of influenza fusion peptide mutants and conformational models

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Research funding. A framework for decisions about research with HPAI H5N1 viruses

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Development of an influenza virologic risk assessment tool

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Estimating age-specific cumulative incidence for the 2009 influenza pandemic: a meta-analysis of A(H1N1)pdm09 serological studies from 19 countries

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Toward a universal influenza virus vaccine: prospects and challenges

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Unstable polymerase-nucleoprotein interaction is not responsible for avian influenza virus polymerase restriction in human cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Rethinking biosafety in research on potential pandemic pathogens

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Report of the 5th meeting on influenza vaccines that induce broad spectrum and long-lasting immune responses, World Health Organization, Geneva, 16-17 November 2011.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Quantitative predictions of binding free energy changes in drug-resistant influenza neuraminidase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Pathogenicity and transmissibility of reassortant H9 influenza viruses with genes from pandemic H1N1 virus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Airborne transmission of influenza A/H5N1 virus between ferrets

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Evolution, safety, and highly pathogenic influenza viruses

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

IFITM3 restricts the morbidity and mortality associated with influenza

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

H5N1 influenza viruses: facts, not fear

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

The M segment of the 2009 new pandemic H1N1 influenza virus is critical for its high transmission efficiency in the guinea pig model

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

The global spread of drug-resistant influenza

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

The ferret as a model organism to study influenza A virus infection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Prevalence of epistasis in the evolution of influenza A surface proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Charting the host adaptation of influenza viruses

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Receptor binding profiles of avian influenza virus hemagglutinin subtypes on human cells as a predictor of pandemic potential

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Permissive secondary mutations enable the evolution of influenza oseltamivir resistance

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Molecular determinants of adaptation of highly pathogenic avian influenza H7N7 viruses to efficient replication in the human host

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Identifying changes in selective constraints: host shifts in influenza.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

The feasibility of using high resolution genome sequencing of influenza A viruses to detect mixed infections and quasispecies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Minimal molecular constraints for respiratory droplet transmission of an avian-human H9N2 influenza A virus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

The influenza virus resource at the National Center for Biotechnology Information

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Highly pathogenic avian influenza viruses with low virulence for chickens in in vivo tests

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Superspreading and the effect of individual variation on disease emergence

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Transmission dynamics and control of severe acute respiratory syndrome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Evolution and ecology of influenza A viruses

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Hemagglutinin activation of pathogenic avian influenza viruses of serotype H7 requires the protease recognition motif R-X-K/R-R

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

H5N1 virus: Transmission studies resume for avian flu.

3 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

Avian flu: Gain-of-function experiments on H7N9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

Gain-of-Function Experiments on H7N9

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

Comment on "Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis"

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

Public health and biosecurity. Adaptations of avian flu virus are a cause for concern

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

A novel strain of Clostridium botulinum that produces type B and type H botulinum toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

Uncertainty in xenotransplantation: individual benefit versus collective risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

Extra oversight for H7N9 experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

Avian flu: Extra oversight for H7N9 experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

Gain-of-function research: unproven technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

Avian influenza: Ferret H7N9 flu model questioned.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

Influenza viruses resistant to the antiviral drug oseltamivir: transmission studies in ferrets

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

Universal vaccine against influenza virus: linking TLR signaling to anti-viral protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PMED.1001646

Redaction of sensitive data in the publication of dual use research of concern

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Gain-of-function experiments on H7N9.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4028196

Elicitation of broadly neutralizing influenza antibodies in animals with previous influenza exposure

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24844931

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Deduced amino acid sequences at the haemagglutinin cleavage site of avian influenza A viruses of H5 and H7 subtypes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24844931

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PMED.1001646

1 reference

14 September 2017

1 reference

PMC publication ID

4028196

14 September 2017

PubMed publication ID

24844931

1 reference

PMC publication ID

4028196