(Q30369189)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

author name string

Joel Karpiak

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Wesley K Kroeze

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Hu Zhu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Xin Chen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Sheryl S Moy

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Kara A Saddoris

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Viktoriya D Nikolova

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Martilias S Farrell

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Sheng Wang

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Thomas J Mangano

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Deepak A Deshpande

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Alice Jiang

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Raymond B Penn

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Jian Jin

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Beverly H Koller

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Terry Kenakin

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Brian K Shoichet

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Bryan L Roth

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

language of work or name

English

0 references

publication date

9 November 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

volume

527

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

issue

7579

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

page(s)

477-483

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily

29 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Role of extracellular proton-sensing OGR1 in regulation of insulin secretion and pancreatic β-cell functions.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Regulation of inflammation by extracellular acidification and proton-sensing GPCRs

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Ovarian cancer G protein coupled receptor 1 suppresses cell migration of MCF7 breast cancer cells via a Gα12/13-Rho-Rac1 pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Automated design of ligands to polypharmacological profiles.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Coupling hippocampal neurogenesis to brain pH through proneurogenic small molecules that regulate proton sensing G protein-coupled receptors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Regulated expression of pH sensing G Protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

ChEMBL: a large-scale bioactivity database for drug discovery

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Predicting new molecular targets for known drugs

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Expression and function of proton-sensing G-protein-coupled receptors in inflammatory pain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Anatomical profiling of G protein-coupled receptor expression

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Quantifying the relationships among drug classes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Relating protein pharmacology by ligand chemistry

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

What makes lorazepam different from other benzodiazepines?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Proton-sensing G-protein-coupled receptors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

G protein-coupled receptor allosterism and complexing

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Clinical pharmacokinetics of lorazepam. I. Absorption and disposition of oral 14C-lorazepam

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation

3 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

The proton-activated G protein coupled receptor OGR1 acutely regulates the activity of epithelial proton transport proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

Rapid context-dependent ligand desolvation in molecular docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

Extracellular acidification stimulates IL-6 production and Ca(2+) mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

Ovarian cancer G protein-coupled receptor 1-dependent and -independent vascular actions to acidic pH in human aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

The role of group I metabotropic glutamate receptors in acquisition and expression of contextual and auditory fear conditioning in rats - a comparison

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

Transient activation of the CA3 Kappa opioid system in the dorsal hippocampus modulates complex memory processing in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

Building alternate protein structures using the elastic network model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

New Class IV Charge Model for Extracting Accurate Partial Charges from Wave Functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

Model for Aqueous Solvation Based on Class IV Atomic Charges and First Solvation Shell Effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

Functional expression of M(1), M(3) and M(5) muscarinic acetylcholine receptors in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

On the Role of the Crystal Environment in Determining Protein Side-chain Conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE15699

A public-private partnership to unlock the untargeted kinome

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4796946

Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells

26 November 2018

1 reference

12 December 2020

Ovarian cancer G-protein-coupled receptor 1 induces the expression of the pain mediator prostaglandin E2 in response to an acidic extracellular environment in human osteoblast-like cells

1 reference

12 December 2020

Ligand-supported homology modeling of g-protein-coupled receptor sites: models sufficient for successful virtual screening

1 reference

12 December 2020

Where will new neuroscience therapies come from?

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE15699

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

journals/nature/HuangKKZCMSNFWM15

29 February 2020

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26550826%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

26550826

1 reference