(Q30373366)

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Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

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PMC publication ID

13 August 2017

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration (English)

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Europe PubMed Central

PMC publication ID

13 August 2017

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Kelvin C Luk

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Nicholas M. Kanaan

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Nicholas M Kanaan

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John Q. Trojanowski

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John Q Trojanowski

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13 August 2017

Kathy Steece-Collier

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Kathy Steece-Collier

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Katrina L Paumier

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Fredric P Manfredsson

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Jack W Lipton

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Timothy J Collier

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Christopher J Kemp

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13 August 2017

Stephanie Celano

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13 August 2017

Emily Schulz

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Ivette M Sandoval

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13 August 2017

Sheila Fleming

12

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Elliott Dirr

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Nicole K Polinski

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Virginia M Lee

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Caryl E Sortwell

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publication date

17 June 2015

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13 August 2017

Neurobiology of Disease

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13 August 2017

82

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13 August 2017

185-199

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13 August 2017

The significance of motor (a)symmetry in Parkinson's disease.

1 reference

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Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates.

1 reference

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Neuroprotective potential of pleiotrophin overexpression in the striatonigral pathway compared with overexpression in both the striatonigral and nigrostriatal pathways.

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Vocalization deficits in mice over-expressing alpha-synuclein, a model of pre-manifest Parkinson's disease

1 reference

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Differential expression of alpha-synuclein in hippocampal neurons

1 reference

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Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system

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Caudo-rostral brain spreading of α-synuclein through vagal connections

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α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

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Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

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Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

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Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease

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α-Synuclein in Parkinson's disease

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Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons

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Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

1 reference

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Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat

1 reference

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Parkinson's disease mouse models in translational research

1 reference

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

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Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model t

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12 December 2020

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10.1016/J.NBD.2015.06.003

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Europe PubMed Central

PMC publication ID

13 August 2017

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Europe PubMed Central

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13 August 2017

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13 August 2017

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