(Q30378420)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

3

1 reference

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22 February 2020

Felix Grassmann

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Rudolf Fuchshofer

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Gernot Längst

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Bernhard H Weber

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

author name string

Ulrike Friedrich

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Shyamtanu Datta

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Karolina Plössl

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Magdalena Schneider

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Klaus-Jürgen Tiefenbach

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

publication date

26 August 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

volume

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

issue

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

page(s)

6361-6373

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ

22 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

The structural basis of mode of activation and functional diversity: a case study with HtrA family of serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Primary structure of a putative serine protease specific for IGF-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Structural and functional analysis of HtrA1 and its subdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

The role of human HtrA1 in arthritic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Matrix remodeling as stem cell recruitment event: a novel in vitro model for homing of human bone marrow stromal cells to the site of injury shows crucial role of extracellular collagen matrix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

HtrA1 inhibits mineral deposition by osteoblasts: requirement for the protease and PDZ domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Elevated expression of serine protease HtrA1 in preeclampsia and its role in trophoblast cell migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Distribution of the serine protease HtrA1 in normal human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Expression and functional significance of HtrA1 loss in endometrial cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Two novel HTRA1 mutations in a European CARASIL patient

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

A novel mutation of the high-temperature requirement A serine peptidase 1 (HTRA1) gene in a Chinese family with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

A missense HTRA1 mutation expands CARASIL syndrome to the Caucasian population

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

A novel mutation in the HTRA1 gene identified in Chinese CARASIL pedigree.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

HTRA1 promoter polymorphism in wet age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Seven new loci associated with age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Optical thermophoresis for quantifying the buffer dependence of aptamer binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Why molecules move along a temperature gradient

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Determining protein stability in cell lysates by pulse proteolysis and Western blotting

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

A "silent" polymorphism in the MDR1 gene changes substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Investigating protein unfolding kinetics by pulse proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Quality control: ER-associated degradation: protein quality control and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Identification of a unique TGF-β-dependent molecular and functional signature in microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Effects of hypoxia on expression of transforming growth factor-beta1 and its receptors I and II in the amoeboid microglial cells and murine BV-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

TGFβ directs gene expression of activated microglia to an anti‐inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

[Transforming growth factor-betas: smad signaling and roles in physiopathology]

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Upregulation of PAI-1 is mediated through TGF-beta/Smad pathway in transplant arteriopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Exposing synonymous mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Hearing silence: non-neutral evolution at synonymous sites in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Mammalian mutation pressure, synonymous codon choice, and mRNA degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Rare codons regulate KRas oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

MDR1 synonymous polymorphisms alter transporter specificity and protein stability in a stable epithelial monolayer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Binding properties of insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-3 N- and C-terminal fragments, and structurally related proteins mac25 and connective tissue growth factor measured using a biosensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Identification of urinary biomarkers for age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Polyethylene glycol (PEG)-induced mouse model of choroidal neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

NBHA reduces acrolein-induced changes in ARPE-19 cells: possible involvement of TGFβ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Subtoxic oxidative stress induces senescence in retinal pigment epithelial cells via TGF-beta release

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Biological effects of native and oxidized low-density lipoproteins in cultured human retinal pigment epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Microglia: The constant gardeners.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Microglia: a sensor for pathological events in the CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Microglia: gatekeepers of central nervous system immunology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Inflammation, apoptosis, and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

The microglial phagocytic role with specific plaque types in the Alzheimer disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Microglial degeneration in the aging brain--bad news for neurons?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Microglia activation in retinal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

A2E accumulation influences retinal microglial activation and complement regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Microglia in the aging retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

TGF-beta1 blockade of microglial chemotaxis toward Abeta aggregates involves SMAD signaling and down-regulation of CCL5

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

An integrated map of genetic variation from 1,092 human genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV346

21 January 2018

Identifiers

DOI

10.1093/HMG/DDV346

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference