(Q37448008)

English

Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo

scientific article published on 05 August 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo (English)

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

1 reference

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author name string

Angela Chamberland

1

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Eunice Wang

2

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Aled R Jones

3

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Lisa A Collins-Racie

4

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Edward R LaVallie

5

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Ying Huang

6

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Lin Liu

7

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Elisabeth A Morris

8

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Carl R Flannery

9

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Zhiyong Yang

10

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

language of work or name

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publication date

5 August 2009

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

284

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

40

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

27352-27359

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

HTRA1 promoter polymorphism in wet age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

The role of human HtrA1 in arthritic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

Implications of the serine protease HtrA1 in amyloid precursor protein processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

The HtrA Family of Proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

Evidence for altered synthesis of type II collagen in patients with osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

23 August 2017

HtrA1 inhibits mineral deposition by osteoblasts: requirement for the protease and PDZ domains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

14 September 2017

Global protein identification and quantification technology using two-dimensional liquid chromatography nanospray mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

14 September 2017

Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

26 June 2018

Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

2 September 2018

Expression and characterization of a serine protease that preferentially cleaves insulin-like growth factor binding protein-5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

2 September 2018

Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785663

2 September 2018

The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19657146

12 December 2020

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Identifiers

10.1074/JBC.M109.037051

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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