(Q30394379)

14 August 2017

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor (English)

1 reference

14 August 2017

0 references

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Marta Filizola

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Arthur Christopoulos

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Samuel Gerritz

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Neil T Burford

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Kathryn E Livingston

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Molly R Ryan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Lauren M L Budenholzer

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Ying Han

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Yi Shang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

John J Herbst

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Jonathan O'Connell

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Martyn Banks

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Litao Zhang

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Daniel L Bassoni

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Tom S Wehrman

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

John R Traynor

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Andrew Alt

18

1 reference

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10 June 2020

language of work or name

English

0 references

publication date

7 May 2015

1 reference

Journal of Medicinal Chemistry

14 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

58

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

4220-4229

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor

10 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Molecular control of δ-opioid receptor signalling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Delta opioid receptors in brain function and diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Signalling bias in new drug discovery: detection, quantification and therapeutic impact.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Opioid receptors: distinct roles in mood disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

A simple method for quantifying functional selectivity and agonist bias

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Ligand-directed signalling within the opioid receptor family

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Measurements of β-arrestin recruitment to activated seven transmembrane receptors using enzyme complementation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

The delta opioid receptor: an evolving target for the treatment of brain disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Delta opioid receptor analgesia: recent contributions from pharmacology and molecular approaches

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Strategies for the identification of allosteric modulators of G-protein-coupled receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Delta and kappa opioid receptors as suitable drug targets for pain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859)

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

A homogeneous enzyme fragment complementation-based beta-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

The antidepressant -like effects of delta-opioid receptor agonists

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

The convulsive and electroencephalographic changes produced by nonpeptidic delta-opioid agonists in rats: comparison with pentylenetetrazol

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

G protein-coupled receptor allosterism and complexing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Identification of selective agonists and positive allosteric modulators for µ- and δ-opioid receptors from a single high-throughput screen

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Allosteric Modulation of G Protein–Coupled Receptors

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Analysis of allosterism in functional assays

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703104

Epik: a software program for pK( a ) prediction and protonation state generation for drug-like molecules

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25901762

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACS.JMEDCHEM.5B00007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

25901762

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25901762%20AND%20SRC:MED&resulttype=core&format=json