(Q30405778)

21 August 2017

Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset (English)

1 reference

21 August 2017

1 reference

14

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John Ioannidis

7

John P A Ioannidis

0 references

Themistocles L Assimes

Themistocles L Assimes

5

0 references

Jerome I Rotter

13

Jerome I Rotter

1 reference

21 August 2017

8

Ulrike Peters

1 reference

21 August 2017

22

Deborah A Nickerson

1 reference

21 August 2017

16

David M Herrington

1 reference

21 August 2017

Christopher J O'Donnell

17

Christopher J O'Donnell

1 reference

21 August 2017

3

Andrew D Johnson

1 reference

21 August 2017

15

Rebecca D Jackson

1 reference

21 August 2017

Adam S Gordon

1

1 reference

21 August 2017

Holly K Tabor

2

1 reference

21 August 2017

Beverly M Snively

4

1 reference

21 August 2017

Paul L Auer

6

1 reference

21 August 2017

Jennifer G Robinson

9

1 reference

21 August 2017

Lara E Sucheston

10

1 reference

21 August 2017

Danxin Wang

11

1 reference

21 August 2017

Nona Sotoodehnia

12

1 reference

21 August 2017

Alexander P Reiner

18

1 reference

21 August 2017

Stephen S Rich

19

1 reference

21 August 2017

Mark J Rieder

20

1 reference

21 August 2017

Michael J Bamshad

21

1 reference

21 August 2017

NHLBI GO Exome Sequencing Project

23

1 reference

21 August 2017

26 November 2013

1 reference

21 August 2017

Human Molecular Genetics

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21 August 2017

23

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21 August 2017

8

1 reference

21 August 2017

1957-1963

1 reference

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants

21 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Evolution and functional impact of rare coding variation from deep sequencing of human exomes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

The functional spectrum of low-frequency coding variation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Improving the assessment of the outcome of nonsynonymous SNVs with a consensus deleteriousness score, Condel.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Genomics and drug response

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Effects of CYP2C19 genotype on outcomes of clopidogrel treatment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Single-nucleotide evolutionary constraint scores highlight disease-causing mutations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Estimation of the warfarin dose with clinical and pharmacogenetic data

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

The pharmocogenomics of warfarin: closing in on personalized medicine

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Distribution and intensity of constraint in mammalian genomic sequence

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Crystal structure of human cytochrome P450 2C9 with bound warfarin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Pharmacogenomics: translating functional genomics into rational therapeutics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Amino acid difference formula to help explain protein evolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

Differential roles of Arg97, Asp293, and Arg108 in enzyme stability and substrate specificity of CYP2C9.

20 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FHMG%2FDDT588

An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

An analysis of the relative effects of VKORC1 and CYP2C9 variants on anticoagulation related outcomes in warfarin-treated patients.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3959810

26 November 2018

Identifiers

DOI

10.1093/HMG/DDT588

1 reference

21 August 2017

1 reference

21 August 2017

PubMed publication ID

24282029

1 reference