(Q30418309)

21 June 2017

Top-down mass spectrometry for the analysis of combinatorial post-translational modifications (English)

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21 June 2017

Claire E Eyers

2

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author name string

Francesco Lanucara

series ordinal

1

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21 June 2017

20 June 2012

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Mass Spectrometry Reviews

21 June 2017

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21 June 2017

32

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21 June 2017

27-42

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21 June 2017

1

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Mass measurement and top-down HPLC/MS analysis of intact monoclonal antibodies on a hybrid linear quadrupole ion trap-Orbitrap mass spectrometer

21 June 2017

1 reference

Stepwise evolution of protein native structure with electrospray into the gas phase, 10(-12) to 10(2) s

21 January 2018

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Top-down identification and characterization of biomolecules by mass spectrometry

21 January 2018

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Electrostatic stabilization of a native protein structure in the gas phase

21 January 2018

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Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

21 January 2018

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Sequence-specific fragmentation of matrix-assisted laser-desorbed protein/peptide ions

21 January 2018

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Intact protein separation by chromatographic and/or electrophoretic techniques for top-down proteomics

21 January 2018

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Potent antibody therapeutics by design

21 January 2018

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Relating electrospray ionization response to nonpolar character of small peptides.

21 January 2018

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Predicting electrospray response from chromatographic retention time.

21 January 2018

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Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry

21 January 2018

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Loss of charged versus neutral heme from gaseous holomyoglobin ions

21 January 2018

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Protein identification using sequential ion/ion reactions and tandem mass spectrometry

21 January 2018

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High resolution electron transfer dissociation studies of unfractionated intact histones from murine embryonic stem cells using on-line capillary LC separation: determination of abundant histone isoforms and post-translational modifications

21 January 2018

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CONSeQuence: prediction of reference peptides for absolute quantitative proteomics using consensus machine learning approaches

21 January 2018

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Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation

21 January 2018

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

21 January 2018

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GSK3 takes centre stage more than 20 years after its discovery

21 January 2018

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Interpreting top-down mass spectra using spectral alignment.

21 January 2018

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Ion-Ion Reactions with Fixed-Charge Modified Proteins to Produce Ions in a Single, Very High Charge State

21 January 2018

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Influence of combinatorial histone modifications on antibody and effector protein recognition

21 January 2018

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The RESID Database of Protein Modifications: 2003 developments

21 January 2018

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Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state

21 January 2018

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Extending top-down mass spectrometry to proteins with masses greater than 200 kilodaltons

21 January 2018

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Top-down sequencing of O-glycoproteins by in-source decay matrix-assisted laser desorption ionization mass spectrometry for glycosylation site analysis

21 January 2018

1 reference

Identification of novel phosphorylation sites on Xenopus laevis Aurora A and analysis of phosphopeptide enrichment by immobilized metal-affinity chromatography

21 January 2018

1 reference

Phosphorylation site identification via ion trap tandem mass spectrometry of whole protein and peptide ions: bovine alpha-crystallin A chain

21 January 2018

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Improved PSD and CID on a MALDI TOFMS.

21 January 2018

1 reference

The Orbitrap: a new mass spectrometer

21 January 2018

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Mechanism of charging and supercharging molecules in electrospray ionization

21 January 2018

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Supercharged protein and peptide ions formed by electrospray ionization

21 January 2018

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Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail

21 January 2018

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Global assessment of combinatorial post-translational modification of core histones in yeast using contemporary mass spectrometry. LYS4 trimethylation correlates with degree of acetylation on the same H3 tail.

21 January 2018

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Analysis of post-translational modifications by LC-MS/MS.

21 January 2018

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Rigorous determination of the stoichiometry of protein phosphorylation using mass spectrometry.

21 January 2018

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Dissociation techniques in mass spectrometry-based proteomics

21 January 2018

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Electron capture dissociation mass spectrometry of tyrosine nitrated peptides

21 January 2018

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Sensitive and specific identification of wild type and variant proteins from 8 to 669 kDa using top-down mass spectrometry

21 January 2018

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

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The many faces of histone lysine methylation

21 January 2018

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ProSight PTM: an integrated environment for protein identification and characterization by top-down mass spectrometry

21 January 2018

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A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome

21 January 2018

1 reference

Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation

21 January 2018

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Heterogeneity of monoclonal antibodies

21 January 2018

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Increasing charge while preserving noncovalent protein complexes for ESI-MS

21 January 2018

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Primary sequence information from intact proteins by electrospray ionization tandem mass spectrometry

21 January 2018

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Monoclonal antibody "gold rush".

21 January 2018

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Informatics and multiplexing of intact protein identification in bacteria and the archaea

21 January 2018

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Processing complex mixtures of intact proteins for direct analysis by mass spectrometry

21 January 2018

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Top-down mass analysis of protein tyrosine nitration: comparison of electron capture dissociation with "slow-heating" tandem mass spectrometry methods

21 January 2018

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Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.

21 January 2018

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Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9

21 January 2018

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Mass spectrometry in the analysis of N-linked and O-linked glycans

21 January 2018

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High-resolution ion isolation with the ion cyclotron resonance capacitively coupled open cell.

21 January 2018

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Free-flow electrophoresis for top-down proteomics by Fourier transform ion cyclotron resonance mass spectrometry

21 January 2018

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Shotgun annotation of histone modifications: a new approach for streamlined characterization of proteins by top down mass spectrometry.

21 January 2018

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Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4.

21 January 2018

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Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry.

21 January 2018

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Analysis of human C1q by combined bottom-up and top-down mass spectrometry: detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites

21 January 2018

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Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells

21 January 2018

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21 January 2018

Why is p53 acetylated?

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'Top down' protein characterization via tandem mass spectrometry

21 January 2018

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Tandem mass spectrometry of ribonuclease A and B: N-linked glycosylation site analysis of whole protein ions

21 January 2018

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Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry

21 January 2018

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Post-translational modifications of integral membrane proteins resolved by top-down Fourier transform mass spectrometry with collisionally activated dissociation

21 January 2018

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Antibody targeted drugs as cancer therapeutics

21 January 2018

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Orbitrap Mass Analyzer – Overview and Applications in Proteomics

21 January 2018

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MALDI imaging mass spectrometry of human tissue: method challenges and clinical perspectives

21 January 2018

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Peptide sequencing by matrix-assisted laser-desorption mass spectrometry

21 January 2018

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The language of covalent histone modifications

21 January 2018

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A novel MALDI LIFT-TOF/TOF mass spectrometer for proteomics

21 January 2018

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Human embryonic stem cell phosphoproteome revealed by electron transfer dissociation tandem mass spectrometry

21 January 2018

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Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue

21 January 2018

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Top-Down Analysis of Small Plasma Proteins Using an LTQ-Orbitrap. Potential for Mass Spectrometry-Based Clinical Assays for Transthyretin and Hemoglobin

21 January 2018

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Analysis of intact protein isoforms by mass spectrometry.

21 January 2018

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Gel-eluted liquid fraction entrapment electrophoresis: an electrophoretic method for broad molecular weight range proteome separation

21 January 2018

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Mapping intact protein isoforms in discovery mode using top-down proteomics

21 January 2018

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Precursor ion independent algorithm for top-down shotgun proteomics.

21 January 2018

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NCα Bond Dissociation Energies and Kinetics in Amide and Peptide Radicals. Is the Dissociation a Non-ergodic Process?

21 January 2018

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Effect of glycosylation on antibody function: implications for genetic engineering

21 January 2018

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A large-scale method to measure absolute protein phosphorylation stoichiometries

21 January 2018

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High throughput characterization of combinatorial histone codes

21 January 2018

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Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a.

21 January 2018

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ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry

21 January 2018

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Characterization of variable regions of monoclonal antibodies by top-down mass spectrometry.

21 January 2018

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Mass spectrometry for structural characterization of therapeutic antibodies

21 January 2018

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Electron Capture Dissociation of Multiply Charged Protein Cations. A Nonergodic Process

21 January 2018

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(Re)Solution of a Protein Fold Without Solution

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MAS.21348

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21 June 2017

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PubMed ID

22718314