(Q30419941)

16 August 2017

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases (English)

1 reference

16 August 2017

13

0 references

Antony J Cutler

Antony J Cutler

3

0 references

Adam S. Butterworth

Adam S Butterworth

15

0 references

Deborah Smyth

Deborah J Smyth

6

0 references

Anders Malarstig

16

Anders Malarstig

1 reference

16 August 2017

18

John A Todd

1 reference

16 August 2017

17

John Danesh

1 reference

16 August 2017

4

Joanna M M Howson

1 reference

16 August 2017

14

Stephen S Rich

1 reference

16 August 2017

5

Daniel B Rainbow

1 reference

16 August 2017

11

Marcin L Pekalski

1 reference

16 August 2017

8

Pamela Clarke

1 reference

16 August 2017

Ricardo C Ferreira

1

1 reference

16 August 2017

Daniel F Freitag

2

1 reference

16 August 2017

Stephen Kaptoge

7

1 reference

16 August 2017

Charlotte Boreham

9

1 reference

16 August 2017

Richard M Coulson

10

1 reference

16 August 2017

Wei-Min Chen

12

1 reference

16 August 2017

language of work or name

1 reference

4 April 2013

1 reference

16 August 2017

1 reference

16 August 2017

9

1 reference

16 August 2017

4

1 reference

16 August 2017

e1003444

1 reference

Creative Commons Attribution 4.0 International

16 August 2017

start time

4 April 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Large-scale association analysis identifies new risk loci for coronary artery disease

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High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

20 June 2018

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Interleukin-6 receptor pathways in abdominal aortic aneurysm

20 June 2018

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Mechanisms of premature atherosclerosis in rheumatoid arthritis and lupus

20 June 2018

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STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.

20 June 2018

1 reference

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The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Systematic review of tocilizumab for rheumatoid arthritis: a new biologic agent targeting the interleukin-6 receptor

20 June 2018

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The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

20 June 2018

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Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

20 June 2018

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A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation

20 June 2018

1 reference

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An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Identification of IL6R and chromosome 11q13.5 as risk loci for asthma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

20 June 2018

1 reference

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Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Evidence that HLA class I and II associations with type 1 diabetes, autoantibodies to GAD and autoantibodies to IA-2, are distinct.

20 June 2018

1 reference

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Epidemiology of CVD in rheumatic disease, with a focus on RA and SLE.

20 June 2018

1 reference

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Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Promise and pitfalls of the Immunochip

20 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Stat3 phosphorylation mediates resistance of primary human T cells to regulatory T cell suppression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

The soluble Interleukin 6 receptor: generation and role in inflammation and cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

LocusZoom: regional visualization of genome-wide association scan results

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Th17 and regulatory T cells in mediating and restraining inflammation

20 June 2018

1 reference

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Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study

20 June 2018

1 reference

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Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells

20 June 2018

1 reference

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Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

20 June 2018

1 reference

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Testing the inflammatory hypothesis of atherothrombosis: scientific rationale for the cardiovascular inflammation reduction trial (CIRT).

20 June 2018

1 reference

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Relation of multiple inflammatory biomarkers to incident atrial fibrillation

20 June 2018

1 reference

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20 June 2018

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Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells

20 June 2018

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20 June 2018

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Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review

20 June 2018

1 reference

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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Th17: the third member of the effector T cell trilogy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Nonredundant roles for Stat5a/b in directly regulating Foxp3

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Type 1 diabetes and coronary artery disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

A new mathematical model for relative quantification in real-time RT-PCR

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Interleukin-6: an overview

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3617094

In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling

20 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003444

Study design and rationale for the Stabilization of pLaques usIng Darapladib—Thrombolysis in Myocardial Infarction (SOLID-TIMI 52) trial in patients after an acute coronary syndrome

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003444

Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003444

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

21 January 2018

1 reference

12 December 2020

Inhibition of secretory phospholipase A(2) in patients with acute coronary syndromes: rationale and design of the vascular inflammation suppression to treat acute coronary syndrome for 16 weeks (VISTA-16) trial

1 reference

12 December 2020

Autoimmune diabetes inflames the heart

1 reference

12 December 2020

The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site

1 reference

12 December 2020

Enhancing the sensitivity of assays to detect T cell reactivity: the effect of cell separation and cryopreservation media

1 reference

12 December 2020

10.1371/JOURNAL.PGEN.1003444

Identifiers

DOI

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

23593036

1 reference