(Q30422344)

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Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development

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scholarly article

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Europe PubMed Central

PMC publication ID

15 August 2017

Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

type-1 diabetes

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object named as

Sarah A Tersey

2

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David A Taylor-Fishwick

object named as

David A Taylor-Fishwick

10

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Raghavendra Mirmira

11

object named as

Raghavendra G Mirmira

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Banumathi K Cole

3

object named as

Banumathi K Cole

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Shamina M Green-Mitchell

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Kaiwen Ma

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Norine S Kuhn

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Tina Duong Cunningham

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Nelly A Maybee

7

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Swarup K Chakrabarti

8

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Marcia McDuffie

9

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Jerry L Nadler

12

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Europe PubMed Central

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15 August 2017

Margaret A Morris

13

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Europe PubMed Central

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15 August 2017

language of work or name

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publication date

21 February 2013

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Europe PubMed Central

PMC publication ID

15 August 2017

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

e56763

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

copyright license

Creative Commons Attribution 4.0 International

21 February 2013

1 reference

April 2022 Public Data File from Crossref

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0 references

The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

TLR4-mediated IL-12 production enhances IFN-γ and IL-1β production, which inhibits TGF-β production and promotes antibody-induced joint inflammation

1 reference

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20 June 2018

Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Progressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Functional and pathological roles of the 12- and 15-lipoxygenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Prediction and pathogenesis in type 1 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Etiology of type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Inflammation and immune regulation by 12/15-lipoxygenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Cellular and molecular mechanisms of the selective regulation of IL-12 production by 12/15-lipoxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

The NOD mouse: a model of immune dysregulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Autoimmune diabetes is blocked in Stat4-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Inhibition of STAT4 activation by lisofylline is associated with the protection of autoimmune diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

20 June 2018

Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056763

21 January 2018

12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056763

21 January 2018

Effect of targeted disruption of signal transducer and activator of transcription (Stat)4 and Stat6 genes on the autoimmune diabetes development induced by multiple low doses of streptozotocin

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056763

21 January 2018

beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056763

21 January 2018

High sensitivity of beta-cell replication to the inhibitory effects of interleukin-1beta: modulation by adenoviral overexpression of IGF2 in rat islets.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056763

21 January 2018

Stat4-null non-obese diabetic mice: protection from diabetes and experimental allergic encephalomyelitis, but with concomitant epitope spread

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0056763

21 January 2018

The role of 12-lipoxygenase in pancreatic -cells (Review).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3578926

26 November 2018

Reducing or increasing β-cell apoptosis without inflammation does not affect diabetes initiation in neonatal NOD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23437231

12 December 2020

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10.1371/JOURNAL.PONE.0056763

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

2013PLoSO...856763G

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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