(Q30431492)

English

Molecular simulations illuminate the role of regulatory components of the RNA polymerase from the hepatitis C virus in influencing protein structure and dynamics

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Molecular simulations illuminate the role of regulatory components of the RNA polymerase from the hepatitis C virus in influencing protein structure and dynamics (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Hepatitis C virus

1 reference

based on heuristic

inferred from title

author name string

Brittny C Davis

1

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Ian F Thorpe

2

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

language of work or name

0 references

publication date

21 June 2013

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

52

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

26

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

4541-4552

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase

1 reference

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A template RNA entry channel in the fingers domain of the poliovirus polymerase

1 reference

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Molecular dynamics simulations of viral RNA polymerases link conserved and correlated motions of functional elements to fidelity

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Allostery and population shift in drug discovery

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Further Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis

1 reference

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RNA-dependent RNA polymerases from flaviviruses and Picornaviridae

1 reference

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Computational identification of slow conformational fluctuations in proteins

1 reference

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A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase

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Structure-function relationships among RNA-dependent RNA polymerases

1 reference

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PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations

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MultiSeq: unifying sequence and structure data for evolutionary analysis

1 reference

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Structure and function of RNA replication

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A comparison of viral RNA-dependent RNA polymerases

1 reference

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The face of future hepatitis C antiviral drug development: recent biological and virologic advances and their translation to drug development and clinical practice

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Unravelling hepatitis C virus replication from genome to function

1 reference

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Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors

1 reference

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PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations

1 reference

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Initiation of viral RNA-dependent RNA polymerization

1 reference

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Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate

1 reference

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Identification of a C-Terminal Regulatory Motif in Hepatitis C Virus RNA-Dependent RNA Polymerase: Structural and Biochemical Analysis

1 reference

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Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation

1 reference

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The essential role of C-terminal residues in regulating the activity of hepatitis C virus RNA-dependent RNA polymerase.

1 reference

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HCV RNA-dependent RNA polymerase as a target for antiviral development

1 reference

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Electrostatics of nanosystems: application to microtubules and the ribosome

1 reference

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20 June 2018

1 reference

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20 June 2018

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

1 reference

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20 June 2018

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

1 reference

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Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy

1 reference

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Structure of the RNA-dependent RNA polymerase of poliovirus

1 reference

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Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus

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Systematic study of anharmonic features in a principal component analysis of gramicidin A.

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Metal ion-binding studies highlight important differences between flaviviral RNA polymerases

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Selected-fit versus induced-fit protein binding: kinetic differences and mutational analysis.

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Dimensionality reduction and visualization in principal component analysis

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Effect of metal ion binding on the structural stability of the hepatitis C virus RNA polymerase

1 reference

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Characterization of the metal ion binding properties of the hepatitis C virus RNA polymerase

1 reference

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26 November 2018

Identifiers

10.1021/BI400251G

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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