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Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels.
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Europe PubMed Central
PMC publication ID
3393774
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22483378%20AND%20SRC:MED&resulttype=core&format=json
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28 January 2020
title
Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3393774
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22483378%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
main subject
fragile X syndrome
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inferred from title
author
Lily Jan
series ordinal
2
1 reference
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Europe PubMed Central
PMC publication ID
3393774
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22483378%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
author name string
Hye Young Lee
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3393774
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22483378%20AND%20SRC:MED&resulttype=core&format=json
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28 January 2020
publication date
5 April 2012
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PMC publication ID
3393774
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retrieved
28 January 2020
published in
Current Opinion in Neurobiology
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PMC publication ID
3393774
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22483378%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
volume
22
1 reference
stated in
Europe PubMed Central
PMC publication ID
3393774
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22483378%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
issue
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
3393774
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22483378%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
page(s)
887-894
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Europe PubMed Central
PMC publication ID
3393774
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22483378%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
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Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome
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20 June 2018
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability
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Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice.
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The distribution and targeting of neuronal voltage-gated ion channels
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20 June 2018
Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels
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20 June 2018
From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome
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20 June 2018
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes
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The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain
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20 June 2018
The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development.
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20 June 2018
The mGluR theory of fragile X mental retardation
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20 June 2018
Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP
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20 June 2018
The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences
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20 June 2018
82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization
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20 June 2018
Sunrise at the synapse: the FMRP mRNP shaping the synaptic interface
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20 June 2018
The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses
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20 June 2018
Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression
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20 June 2018
Altered synaptic plasticity in a mouse model of fragile X mental retardation
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20 June 2018
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
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20 June 2018
Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
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20 June 2018
The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
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20 June 2018
Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
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20 June 2018
Abnormal development of dendritic spines in FMR1 knock-out mice
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20 June 2018
Synaptic regulation of protein synthesis and the fragile X protein
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20 June 2018
The fragile X mental retardation protein inhibits translation via interacting with mRNA
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20 June 2018
Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination.
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20 June 2018
Evidence that fragile X mental retardation protein is a negative regulator of translation
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20 June 2018
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
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20 June 2018
Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones
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20 June 2018
Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits
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20 June 2018
Inward rectifier potassium channels
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20 June 2018
Characterization and localization of the FMR-1 gene product associated with fragile X syndrome
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20 June 2018
A point mutation in the FMR-1 gene associated with fragile X mental retardation
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PubMed Central
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20 June 2018
The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation
1 reference
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PubMed Central
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20 June 2018
FMR1 protein: conserved RNP family domains and selective RNA binding
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20 June 2018
Speech disturbances (cluttering) in mildly impaired males with the Martin-Bell/fragile X syndrome.
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20 June 2018
Absence of expression of the FMR-1 gene in fragile X syndrome
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PubMed Central
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20 June 2018
Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox
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20 June 2018
Analysis of neocortex in three males with the fragile X syndrome
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PubMed Central
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20 June 2018
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
20 June 2018
Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
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26 November 2018
Identification of novel FMR1 variants by massively parallel sequencing in developmentally delayed males
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Phosphorylation of FMRP inhibits association with Dicer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Fragile X syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Compartmentalized dendritic plasticity and input feature storage in neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Regulation of Kv4.2 channels by glutamate in cultured hippocampal neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Reducing glutamate signaling pays off in fragile X.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Prolonged epileptiform discharges induced by altered group I metabotropic glutamate receptor-mediated synaptic responses in hippocampal slices of a fragile X mouse model.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the FMR1 null mouse.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Phosphorylation influences the translation state of FMRP-associated polyribosomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Electrodermal responses to sensory stimuli in individuals with fragile X syndrome: a preliminary report.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393774
retrieved
26 November 2018
Analysis of the fragile-X chromosome: localization and detection of the fragile site in high resolution preparations
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22483378
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mosaic FMR1 deletion causes fragile X syndrome and can lead to molecular misdiagnosis: a case report and review of the literature
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22483378
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CONB.2012.03.010
1 reference
stated in
Europe PubMed Central
PMC publication ID
3393774
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22483378%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
PMC publication ID
3393774
1 reference
stated in
Europe PubMed Central
PMC publication ID
3393774
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22483378%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
PubMed publication ID
22483378
1 reference
stated in
Europe PubMed Central
PMC publication ID
3393774
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22483378%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 January 2020
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